Clonal hematopoiesis and atherosclerosis
Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a previously
unrecognized, potent, age-related, and common risk factor for atherosclerosis. Somatic …
unrecognized, potent, age-related, and common risk factor for atherosclerosis. Somatic …
TET Enzymes in the Immune system: from DNA demethylation to immunotherapy, inflammation, and cancer
IF López-Moyado, M Ko, PG Hogan… - Annual Review of …, 2024 - annualreviews.org
Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …
Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis
Abstract Background and Aims Somatic mutations in the TET2 gene that lead to clonal
haematopoiesis (CH) are associated with accelerated atherosclerosis development in mice …
haematopoiesis (CH) are associated with accelerated atherosclerosis development in mice …
Clonal hematopoiesis, cardiovascular events and treatment benefit in 63,700 individuals from five TIMI randomized trials
Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with an
increased risk of cardiovascular (CV) disease in the general population. Currently, it is …
increased risk of cardiovascular (CV) disease in the general population. Currently, it is …
TET3-overexpressing macrophages promote endometriosis
H Lv, B Liu, Y Dai, F Li, S Bellone, Y Zhou… - The Journal of Clinical …, 2024 - jci.org
Endometriosis is a debilitating, chronic inflammatory disease affecting approximately 10% of
reproductive-age women worldwide with no cure. While macrophages have been …
reproductive-age women worldwide with no cure. While macrophages have been …
[HTML][HTML] Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba
Bioactive compounds derived from herbal medicinal plants modulate various therapeutic
targets and signaling pathways associated with cardiovascular diseases (CVDs), the world's …
targets and signaling pathways associated with cardiovascular diseases (CVDs), the world's …
BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis
M Yalcinkaya, W Liu, LA Thomas, M Olszewska… - Circulation, 2023 - Am Heart Assoc
BACKGROUND: Clonal hematopoiesis (CH) has emerged as an independent risk factor for
atherosclerotic cardiovascular disease, with activation of macrophage inflammasomes as a …
atherosclerotic cardiovascular disease, with activation of macrophage inflammasomes as a …
Omics approaches unveiling the biology of human atherosclerotic plaques
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
buildup of plaques with the accumulation and transformation of lipids, immune cells …
buildup of plaques with the accumulation and transformation of lipids, immune cells …
Nonpreferential but Detrimental Accumulation of Macrophages With Clonal Hematopoiesis-Driver Mutations in Cardiovascular Tissues—Brief Report
TS Dederichs, A Yerdenova, H Horstmann… - … , and vascular biology, 2024 - Am Heart Assoc
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is an acquired
genetic risk factor for both leukemia and cardiovascular disease. It results in proinflammatory …
genetic risk factor for both leukemia and cardiovascular disease. It results in proinflammatory …
Modification of Breakfast Fat Composition Can Modulate Cytokine and Other Inflammatory Mediators in Women: A Randomized Crossover Trial
JM Delgado-Alarcón, JJ Hernández Morante… - Nutrients, 2023 - mdpi.com
Previous trials have demonstrated that modifying dietary fat composition can influence the
production of inflammation-related factors. Additionally, it has been suggested that not only …
production of inflammation-related factors. Additionally, it has been suggested that not only …