Analysis of metagenomic data

S Liu, JS Rodriguez, V Munteanu… - Nature Reviews …, 2025 - nature.com
Metagenomics has revolutionized our understanding of microbial communities, offering
unprecedented insights into their genetic and functional diversity across Earth's diverse …

GSearch: ultra-fast and scalable genome search by combining K-mer hashing with hierarchical navigable small world graphs

J Zhao, JP Both, LM Rodriguez-R… - Nucleic Acids …, 2024 - academic.oup.com
Genome search and/or classification typically involves finding the best-match database
(reference) genomes and has become increasingly challenging due to the growing number …

MegIS: High-Performance, Energy-Efficient, and Low-Cost Metagenomic Analysis with In-Storage Processing

NM Ghiasi, M Sadrosadati, H Mustafa… - 2024 ACM/IEEE 51st …, 2024 - ieeexplore.ieee.org
Metagenomics, the study of the genome sequences of diverse organisms in a common
environment, has led to significant advances in many fields. Since the species present in a …

HyperGen: compact and efficient genome sketching using hyperdimensional vectors

W Xu, PK Hsu, N Moshiri, S Yu, T Rosing - Bioinformatics, 2024 - academic.oup.com
Motivation Genomic distance estimation is a critical workload since exact computation for
whole-genome similarity metrics such as Average Nucleotide Identity (ANI) incurs prohibitive …

Employing bimodal representations to predict DNA bendability within a self-supervised pre-trained framework

M Yang, S Zhang, Z Zheng, P Zhang… - Nucleic Acids …, 2024 - academic.oup.com
The bendability of genomic DNA, which measures the DNA looping rate, is crucial for
numerous biological processes of DNA. Recently, an advanced high-throughput technique …

Metagenomic functional profiling: to sketch or not to sketch?

MR Hera, S Liu, W Wei, JS Rodriguez, C Ma… - …, 2024 - academic.oup.com
Motivation Functional profiling of metagenomic samples is essential to decipher the
functional capabilities of microbial communities. Traditional and more widely used functional …

MetaFast: Enabling Fast Metagenomic Classification via Seed Counting and Edit Distance Approximation

AE Gollwitzer, M Alser, J Bergtholdt… - arXiv preprint arXiv …, 2023 - arxiv.org
Metagenomics, the study of genome sequences of diverse organisms cohabiting in a shared
environment, has experienced significant advancements across various medical and …

How scalable are clade-specific marker K-Mer based hash methods for metagenomic taxonomic classification?

M Gray, Z Zhao, GL Rosen - Frontiers in Signal Processing, 2022 - frontiersin.org
Efficiently and accurately identifying which microbes are present in a biological sample is
important to medicine and biology. For example, in medicine, microbe identification allows …

MetaStore: High-Performance Metagenomic Analysis via In-Storage Computing

NM Ghiasi, M Sadrosadati, H Mustafa… - arXiv preprint arXiv …, 2023 - arxiv.org
Metagenomics has led to significant advancements in many fields. Metagenomic analysis
commonly involves the key tasks of determining the species present in a sample and their …

GSearch: Ultra-Fast and Scalable Microbial Genome Search by Combining K-mer Hashing with Hierarchical Navigable Small World Graphs

J Zhao, JP Both, LM Rodriguez-R, KT Konstantinidis - bioRxiv, 2022 - biorxiv.org
Genome search and/or classification is a key step in microbiome studies and has recently
become more challenging due to the increasing number of available (reference) genomes …