Engineering considerations of iPSC-based personalized medicine
Personalized medicine aims to provide tailored medical treatment that considers the clinical,
genetic, and environmental characteristics of patients. iPSCs have attracted considerable …
genetic, and environmental characteristics of patients. iPSCs have attracted considerable …
Progress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models
In recent years, drug development costs have soared, primarily due to the failure of
preclinical animal and cell culture models, which do not directly translate to human …
preclinical animal and cell culture models, which do not directly translate to human …
[HTML][HTML] DoubletDecon: deconvoluting doublets from single-cell RNA-sequencing data
Methods for single-cell RNA sequencing (scRNA-seq) have greatly advanced in recent
years. While droplet-and well-based methods have increased the capture frequency of cells …
years. While droplet-and well-based methods have increased the capture frequency of cells …
Use of human induced pluripotent stem cell–derived cardiomyocytes to assess drug cardiotoxicity
Cardiotoxicity has historically been a major cause of drug removal from the pharmaceutical
market. Several chemotherapeutic compounds have been noted for their propensities to …
market. Several chemotherapeutic compounds have been noted for their propensities to …
[HTML][HTML] Autologous iPSC-based vaccines elicit anti-tumor responses in vivo
Cancer cells and embryonic tissues share a number of cellular and molecular properties,
suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor …
suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor …
iPS-cell technology and the problem of genetic instability—Can it ever be safe for clinical use?
SW Attwood, MJ Edel - Journal of clinical medicine, 2019 - mdpi.com
The use of induced Pluripotent Stem Cells (iPSC) as a source of autologous tissues shows
great promise in regenerative medicine. Nevertheless, several major challenges remain to …
great promise in regenerative medicine. Nevertheless, several major challenges remain to …
Human-induced pluripotent stem cells in cardiovascular research: current approaches in cardiac differentiation, maturation strategies, and scalable production
Manifestations of cardiovascular diseases (CVDs) in a patient or a population differ based
on inherent biological makeup, lifestyle, and exposure to environmental risk factors. These …
on inherent biological makeup, lifestyle, and exposure to environmental risk factors. These …
cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes
EAK DePasquale, D Schnell, P Dexheimer… - Nucleic acids …, 2019 - academic.oup.com
To understand the molecular pathogenesis of human disease, precision analyses to define
alterations within and between disease-associated cell populations are desperately needed …
alterations within and between disease-associated cell populations are desperately needed …
Building gut from scratch—progress and update of intestinal tissue engineering
Short bowel syndrome (SBS), a condition defined by insufficient absorptive intestinal
epithelium, is a rare disease, with an estimated prevalence up to 0.4 in 10,000 people …
epithelium, is a rare disease, with an estimated prevalence up to 0.4 in 10,000 people …
Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers
A Apavaloaei, L Hesnard, MP Hardy, B Benabdallah… - Cell Reports, 2022 - cell.com
Previous reports showed that mouse vaccination with pluripotent stem cells (PSCs) induces
durable anti-tumor immune responses via T cell recognition of some elusive oncofetal …
durable anti-tumor immune responses via T cell recognition of some elusive oncofetal …