Autoimmune diseases (AID) are increasingly prevalent conditions which comprise more
than 100 distinct clinical entities that are responsible for a great disease burden worldwide …

The global COVID-19 pandemic has the potential to severely affect those with rheumatic
diseases or who are taking immunosuppressive therapies. Information is lacking as to how …

Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of
rheumatoid arthritis (RA) owing to their ability to generate citrullinated proteins—the …

Measurement of two groups of autoantibodies, rheumatoid factor (RF) and anti-citrullinated
protein/peptide antibodies (ACPA) have gained increasing significance in the diagnosis and …

Background Rheumatoid arthritis (RA) is classified as seropositive or seronegative,
depending on the presence/absence of rheumatoid factor (RF), primarily IgM RF, and/or anti …

The current review uses rheumatoid arthritis (RA) as a prominent example for how studies
on the interplay between environmental and genetic factors in defined subsets of a disease …

B cells are postulated to be central in seropositive rheumatoid arthritis (RA). Here, we use
exploratory mass cytometry (n= 23) and next-generation sequencing (n= 19) to study B-cell …

Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor
(RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities. Yet …

Rheumatoid arthritis (RA) is caused by prolonged periodic interactions between genetic,
environmental, and immunologic factors. Posttranslational modifications (PTMs) such as …

Anti-citrullinated protein antibodies (ACPAs) are autoantibodies commonly observed in
patients with rheumatoid arthritis (RA). Currently, most of the mechanisms of ACPA formation …