Comparative genomics has recently provided unprecedented insights into the biology and
evolution of the fungal lineage. In the postgenomics era, a major research interest focuses …

Mammalian Rap1, the most conserved telomere-interacting protein, beyond its role within
nucleus for the maintenance of telomeric functions, is also well known for its pleiotropic …

We developed a method to tag telomeres and measure telomere length by nanopore
sequencing in the yeast S. cerevisiae. Nanopore allows long-read sequencing through the …

The yeast Rif2 protein is known to inhibit Mre11 nuclease and the activation of Tel1 kinase
through a short motif termed MIN, which binds the Rad50 subunit and simulates its ATPase …

Specific proteins present at telomeres ensure chromosome end stability, in large part
through unknown mechanisms. In this work, we address how the Saccharomyces cerevisiae …

New work shows that in mammals, the iDDR motif of telomere factor TRF2 inhibits the
MRE11–RAD50–NBS1 (MRN) complex at chromosome ends through a direct iDDR–RAD50 …

The MRN complex (MRX in Saccharomyces cerevisiae, made of Mre11, Rad50 and
Nbs1/Xrs2) initiates double-stranded DNA break repair and activates the Tel1/ATM kinase in …

Early work by Muller and McClintock discovered that the physical ends of linear
chromosomes, named telomeres, possess an inherent ability to escape unwarranted …

Summary The Mre11-Rad50-Xrs2 (MRX) complex detects and processes DNA double-
strand breaks (DSBs). Its DNA binding and processing activities are regulated by transitions …

Telomeres protect chromosome ends from unscheduled DNA repair, including from the
MRN (MRE11, RAD50, NBS1) complex, which processes double-stranded DNA breaks …