Vagal sensory neurons constitute the major afferent supply to the airways and lungs.
Subsets of afferents are defined by their embryological origin, molecular profile …

Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …

Nociception is the process whereby primary afferent nerve fibers of the somatosensory
system detect noxious stimuli. Pungent irritants from pepper, mint, and mustard plants have …

Specialized peripheral sensory neurons known as nociceptors alert us to potentially
damaging stimuli at the skin by detecting extremes in temperature and pressure and injury …

Aminoglycoside antibiotics are used as prophylaxis, or urgent treatment, for many life-
threatening bacterial infections, including tuberculosis, sepsis, respiratory infections in cystic …

Gram-negative bacterial infections are accompanied by inflammation and somatic or
visceral pain. These symptoms are generally attributed to sensitization of nociceptors by …

Nociception and pain is a large field of both neuroscience and medical research. Over time,
various tests and models were developed in rodents to provide tools for fundamental and …

Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

Transient receptor potential (TRP) channels are a large family of ion channel proteins,
surpassed in number in mammals only by voltage-gated potassium channels. TRP channels …

Pain results from the complex processing of neural signals at different levels of the central
nervous system, with each signal potentially offering multiple opportunities for …