Beyond the hippocampus and the SVZ: adult neurogenesis throughout the brain

MP Jurkowski, L Bettio, E K. Woo, A Patten… - Frontiers in cellular …, 2020 - frontiersin.org
Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …

Post-stroke neurogenesis: friend or foe?

MI Cuartero, A García-Culebras… - Frontiers in Cell and …, 2021 - frontiersin.org
The substantial clinical burden and disability after stroke injury urges the need to explore
therapeutic solutions. Recent compelling evidence supports that neurogenesis persists in …

Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke

F Luo, J Wang, Z Zhang, Z You, A Bedolla… - Cell reports, 2022 - cell.com
In addition to neuroprotective strategies, neuroregenerative processes could provide targets
for stroke recovery. However, the upregulation of inhibitory chondroitin sulfate proteoglycans …

RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury

X Zhu, J Yan, C Bregere, A Zelmer, T Goerne… - Nature …, 2019 - nature.com
Hypoxic ischemia (HI) is an acute brain threat across all age groups. Therapeutic
hypothermia ameliorates resulting injury in neonates but its side effects prevent routine use …

Transplantation of 3D MSC/HUVEC spheroids with neuroprotective and proangiogenic potentials ameliorates ischemic stroke brain injury

TW Hsu, YJ Lu, YJ Lin, YT Huang, LH Hsieh, BH Wu… - Biomaterials, 2021 - Elsevier
Ischemic stroke, and the consequent brain cell death, is a common cause of death and
disability worldwide. Current treatments that primarily aim to relieve symptoms are relatively …

Adult neurogenesis: A story ranging from controversial new neurogenic areas and human adult neurogenesis to molecular regulation

P Leal-Galicia, ME Chávez-Hernández, F Mata… - International journal of …, 2021 - mdpi.com
The generation of new neurons in the adult brain is a currently accepted phenomenon. Over
the past few decades, the subventricular zone and the hippocampal dentate gyrus have …

Microglia Negatively Regulate the Proliferation and Neuronal Differentiation of Neural Stem/Progenitor Cells Isolated from Poststroke Mouse Brains

Y Hirano, T Nakagomi, A Nakano-Doi, S Kubo… - Cells, 2023 - mdpi.com
We previously demonstrated that neural stem/progenitor cells (NSPCs) were induced within
and around the ischemic areas in a mouse model of ischemic stroke. These injury/ischemia …

Light Alcohol Consumption Promotes Early Neurogenesis Following Ischemic Stroke in Adult C57BL/6J Mice

J Li, C Li, P Subedi, X Tian, X Lu, S Miriyala… - Biomedicines, 2023 - mdpi.com
Ischemic stroke is one of the leading causes of death and disability worldwide.
Neurogenesis plays a crucial role in postischemic functional recovery. Alcohol dose …

Newly generated and non-newly generated “immature” neurons in the mammalian brain: a possible reservoir of young cells to prevent brain aging and disease?

C La Rosa, M Ghibaudi, L Bonfanti - Journal of clinical medicine, 2019 - mdpi.com
Brain plasticity is important for translational purposes since most neurological disorders and
brain aging problems remain substantially incurable. In the mammalian nervous system …

New neurons in the post-ischemic and injured brain: Migrating or resident?

NM Nemirovich-Danchenko… - Frontiers in …, 2019 - frontiersin.org
The endogenous potential of adult neurogenesis is of particular interest for the development
of new strategies for recovery after stroke and traumatic brain injury. These pathological …