Adaptive immunity is mediated by T‐and B‐cells, which are immune cells capable of
developing pathogen‐specific memory that confers immunological protection. Memory and …

Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …

Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are
revolutionizing cancer treatment. To unravel the genomic determinants of response to this …

Predictions of epitopes presented by class II human leukocyte antigen molecules (HLA-II)
have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased …

Accumulating evidence suggests that clinically efficacious cancer immunotherapies are
driven by T cell reactivity against DNA mutation–derived neoantigens. However, among the …

T-cells have to recognize peptides presented on MHC molecules to be activated and elicit
their effector functions. Several studies demonstrate that some peptides are more …

Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive
Melanoma | Journal of Clinical Oncology Skip to main content ASCO Publications Publications …

Background The generation of interferon-gamma (IFN-γ) by MHC class II activated CD4+ T
helper cells play a substantial contribution in the control of infections such as caused by …

The interaction between antibodies and antigens is one of the most important immune
system mechanisms for clearing infectious organisms from the host. Antibodies bind to …

We present a new approach to the study of the immune system that combines techniques of
systems biology with information provided by data-driven prediction methods. To this end …