Copper is an important micronutrient required as a redox co-factor in the catalytic centers of
enzymes. However, free copper is a potential hazard because of its high chemical reactivity …

Covering: up to the end of 2009 A key property of metallo-proteins and-enzymes is the
affinity of metal ion M for protein ligand P as defined by the dissociation constant …

Literature estimates of metal-protein affinities are widely scattered for many systems, as
highlighted by the class of metallo-chaperone proteins, which includes human Atox1. The …

Prokaryotic organisms have evolved the capacity to quickly adapt to a changing and
challenging microenvironment in which the availability of both biologically required and non …

In this work we describe the identification of a copper‐inducible regulon in Mycobacterium
tuberculosis (Mtb). Among the regulated genes was Rv0190/MT0200, a paralogue of the …

How cells regulate the bioavailability of utilizable sulfur while mitigating the effects of
hydrogen sulfide toxicity is poorly understood. CstR [C opper‐sensing operon repressor (C …

All strains of Staphylococcus aureus encode a putative copper-sensitive operon repressor
(CsoR) and one other CsoR-like protein of unknown function. We show here that …

Streptococcus pneumoniae D39 AdcR (adhesin competence repressor) is the first metal-
sensing member of the MarR (multiple antibiotic resistance repressor) family to be …

Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

As complications associated with antibiotic resistance have intensified, copper (Cu) is
attracting attention as an antimicrobial agent. Recent studies have shown that copper …