Development of L-asparaginase biobetters: current research status and review of the desirable quality profiles
LP Brumano, FVS da Silva, TA Costa-Silva… - … in bioengineering and …, 2019 - frontiersin.org
L-Asparaginase (ASNase) is a vital component of the first line treatment of acute
lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over …
lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over …
Therapeutic l-asparaginase: upstream, downstream and beyond
AM Lopes, L Oliveira-Nascimento… - Critical reviews in …, 2017 - Taylor & Francis
Abstract l-asparaginase (l-asparagine amino hydrolase, EC 3.5. 1.1) is an enzyme clinically
accepted as an antitumor agent to treat acute lymphoblastic leukemia and lymphosarcoma …
accepted as an antitumor agent to treat acute lymphoblastic leukemia and lymphosarcoma …
[HTML][HTML] Circumventing the side effects of L-asparaginase
MHG Fonseca, T da Silva Fiúza, SB de Morais… - Biomedicine & …, 2021 - Elsevier
L-asparaginase is an enzyme that catalyzes the degradation of asparagine and successfully
used in the treatment of acute lymphoblastic leukemia. L-asparaginase toxicity is either …
used in the treatment of acute lymphoblastic leukemia. L-asparaginase toxicity is either …
A critical review on properties and applications of microbial l-asparaginases
PR Krishnapura, PD Belur… - Critical reviews in …, 2016 - Taylor & Francis
Abstract l-Asparaginase is one of the main drugs used in the treatment of acute
lymphoblastic leukemia (ALL), a commonly diagnosed pediatric cancer. Although several …
lymphoblastic leukemia (ALL), a commonly diagnosed pediatric cancer. Although several …
Molecular analysis of L-asparaginases for clarification of the mechanism of action and optimization of pharmacological functions
MV Pokrovskaya, VS Pokrovsky, SS Aleksandrova… - Pharmaceutics, 2022 - mdpi.com
L-asparaginases (EC 3.5. 1.1) are a family of enzymes that catalyze the hydrolysis of L-
asparagine to L-aspartic acid and ammonia. These proteins with different biochemical …
asparagine to L-aspartic acid and ammonia. These proteins with different biochemical …
Effective mitigation in the amount of acrylamide through enzymatic approaches
Acrylamide (AA), as a food-borne toxicant, is created at some stages of thermal processing
in the starchy food through Maillard reaction, fatty food via acrolein route, and proteinous …
in the starchy food through Maillard reaction, fatty food via acrolein route, and proteinous …
Critical overview of the main features and techniques used for the evaluation of the clinical applicability of L-asparaginase as a biopharmaceutical to treat blood …
TA Costa-Silva, IM Costa, HP Biasoto, GM Lima… - Blood Reviews, 2020 - Elsevier
L-asparaginase is an enzyme used as a biopharmaceutical to treat acute lymphoblastic
leukemia. Several adverse effects have been related to L-asparaginase use, so the scientific …
leukemia. Several adverse effects have been related to L-asparaginase use, so the scientific …
A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro
L-Asparaginases (ASNases) have been used as first line drugs for paediatric Acute
Lymphoblastic Leukaemia (ALL) treatment for more than 40 years. Both the Escherichia coli …
Lymphoblastic Leukaemia (ALL) treatment for more than 40 years. Both the Escherichia coli …
[HTML][HTML] Preclinical evaluation of engineered L-asparaginase variants to improve the treatment of Acute Lymphoblastic Leukemia
S Sengupta, M Biswas, KA Gandhi, SK Gupta… - Translational …, 2024 - Elsevier
Introduction Escherichia coli l-asparaginase (EcA), an integral part of multi-agent
chemotherapy protocols of acute lymphoblastic leukemia (ALL), is constrained by safety …
chemotherapy protocols of acute lymphoblastic leukemia (ALL), is constrained by safety …
Molecular Modeling and Optimization of Type II E.coli l-Asparginase Activity by in silico Design and in vitro Site-directed Mutagenesis
M Mahboobi, AH Salmanian, H Sedighian… - The Protein Journal, 2023 - Springer
Introduction L-asparaginase (also known as L-ASNase) is a crucial therapeutic enzyme that
is widely used in treatment of ALL (acute lymphoblastic leukemia) as a chemotherapeutic …
is widely used in treatment of ALL (acute lymphoblastic leukemia) as a chemotherapeutic …