Fluoroquinolone resistance in Mycobacterium tuberculosis has become increasingly
important. A review of mutations in DNA gyrase, the fluoroquinolone target, is needed to …

Background The detection of mutations in the gyrA and gyrB genes in the Mycobacterium
tuberculosis genome that have been demonstrated to confer phenotypic resistance to …

Fluoroquinolone antibiotics are among the most potent second-line drugs used for treatment
of multidrug-resistant tuberculosis (MDR TB), and resistance to this class of antibiotics is one …

The modulation of DNA topology by DNA gyrase and topoisomerase IV, both of which are
type IIA topoisomerases and found in most bacteria, is a function vital to DNA replication …

Objectives Mutations in the gyrase genes cause fluoroquinolone resistance in
Mycobacterium tuberculosis. However, the predictive value of these markers for clinical …

In this study, a total of 77 multidrug-resistant and extensively drug-resistant (MDR and XDR,
respectively) isolates of Mycobacterium tuberculosis were characterized among samples …

China is one of the countries with the highest burdens of multidrug-resistant (MDR) and
fluoroquinolone (FQ)-resistant tuberculosis (TB) globally. Nevertheless, knowledge about …

The purpose of the present study was to analyse mutations in the gyrA and gyrB genes of
Mycobacterium tuberculosis and define the possible correlation between these mutations …

Background Improving our understanding of the relationship between the genotype and the
drug resistance phenotype of Mycobacterium tuberculosis will aid the development of more …

Fluoroquinolone (FQ) resistance is emerging in Mycobacterium tuberculosis. The main
mechanism of FQ resistance is amino acid substitution within the quinolone resistance …