As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

The nuclear factor-κB (NF-κB) signaling pathway is one of the best understood immune-
related pathways thanks to almost four decades of intense research. NF-κB signaling is …

Synthetic gene circuits that precisely control human cell function could expand the
capabilities of gene-and cell-based therapies. However, platforms for developing circuits in …

Dendritic cells (DCs) are antigen-presenting cells controlling T cell activation. In humans, the
diversity, ontogeny, and functional capabilities of DC subsets are not fully understood. Here …

Although conventional innate immune stimuli contribute to immune activation, they induce
exhausted immune cells, resulting in suboptimal cancer immunotherapy. Here we suggest a …

Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …

Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve
T cell activation and effector differentiation. They are, likewise, involved in the induction and …

Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for
harnessing the potential of a patient's own immune system to eliminate tumor cells in …

In multicellular organisms, dedicated regulatory circuits control cell type diversity and
responses. The crosstalk and redundancies within these circuits and substantial cellular …

Outer membrane vesicles (OMVs) are produced by Gram-negative bacteria both in vitro and
in vivo. OMVs are nano-sized spherical vehicles formed by lipid bilayer membranes and …