Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …

Telomeres are essential for genome stability. Oxidative stress caused by excess reactive
oxygen species (ROS) accelerates telomere shortening. Although telomeres are …

Aging is associated with the accumulation of cellular damage over the course of a lifetime.
This process is promoted in large part by reactive oxygen species (ROS) generated via …

DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …

Genetic defects in the repair of DNA single-strand breaks (SSBs) can result in neurological
disease triggered by toxic activity of the single-strand-break sensor protein PARP1 …

Abstract The Oxidative Stress Theory of Aging has had tremendous impact in research
involving aging and age-associated diseases including those that affect the nervous system …

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is well recognized
as a critical regulator of redox, metabolic, and protein homeostasis, as well as the regulation …

Aging is a multifactorial process that depends on diverse molecular and cellular
mechanisms, such as genome maintenance and inflammation. The nuclear enzyme poly …

We report herein a simple and convenient luminescent assay for detection of base excision
repair enzyme activity using an Ir (III) complex as a G-quadruplex selective probe. Using …