Enabled by high-throughput sequencing approaches, epithelial cancers across a range of
tissue types are seen to harbor gene fusions as integral to their landscape of somatic …

Abtract Forkhead box A1 (FOXA1) is a pioneer transcription factor that is essential for the
normal development of several endoderm-derived organs, including the prostate gland …

Gene fusions result from either structural chromosomal rearrangement or aberrations
caused by splicing or transcriptional readthrough. The precise and distinctive presence of …

Background A significant subset of prostate cancer (PC) patients with a castration-resistant
form of the disease (CRPC) show primary resistance to androgen receptor (AR)-targeting …

To understand functional consequences of genetic and transcriptional aberrations in
prostate cancer, the proteomic changes during disease formation and progression need to …

While hundreds of cancer-associated long noncoding RNAs (lncRNAs) have been
discovered, their functional role in cancer cells is still largely a mystery. An increasing …

Castration-resistant prostate cancers (CRPC) that arise after the failure of androgen-
blocking therapies cause most of the deaths from prostate cancer, intensifying the need to …

Androgens are steroid hormones governing the male reproductive development and
function. As such, androgens and the key mediator of their effects, androgen receptor (AR) …

Abstract Treatment of prostate cancer confronts resistance to androgen receptor (AR)-
targeted therapies. AR-associated coregulators and chromatin proteins hold a great …

The three oncogenic PIM family kinases have been implicated in the development of
prostate cancer (PCa). The aim of this study was to examine the mRNA and protein …