Rationale Adolescence is a developmental period of complex neurobiological change and
heightened vulnerability to psychiatric illness. As a result, understanding factors such as sex …

Pharmaceutical drugs have become consumer products, with a daily use for some of them.
The volume of production and consumption of drugs is such that they have become …

Background Studies of biomarkers of hypothalamic-pituitary-adrenal activity indicate that
psychotic disorders are associated with elevated cortisol. This study examined cortisol levels …

Evidence obtained in recent decades has demonstrated that the brain still matures in
adolescence. Changes in neural connectivity occur in different regions, including cortical …

Suicide is the second leading cause of death in youth globally; however, there is uncertainty
about how best to intervene. Suicide rates are typically higher in males than females, while …

Background Prenatal chemical exposures may adversely affect neurodevelopment, but few
studies have examined the persistence of these associations. We examined whether …

Depression in adolescents is a major public health disorder. The relationship between
physical activity and risk of depression in adolescents was examined using three waves of …

Adolescence is a highly dynamic period of development, which includes the final
organizational phases of neural maturation within the prefrontal cortex (PFC). The …

The onset of puberty has been a fascinating topic for reproductive endocrinologists for
decades; however, its underlying physiological mechanisms have remained elusive until …

This article is part of a Special Issue “Puberty and Adolescence”. The notion that
adolescence is characterized by dramatic changes in behavior, and often by emotional …