Tissue factor (TF) is the high-affinity receptor and cofactor for factor (F) VII/VIIa. The TF-FVIIa
complex is the primary initiator of blood coagulation and plays an essential role in …

Atherosclerosis is a silent chronic vascular pathology that is the cause of the majority of
cardiovascular ischaemic events. The evolution of vascular disease involves a combination …

Objective—Coronary artery thrombosis can occur in the absence of plaque rupture because
of superficial erosion. Erosion-prone atheromata associate with more neutrophil …

The presence of macrophages within the plaque is a defining hallmark of atherosclerosis.
Macrophages are exposed to various microenvironments such as oxidized lipids and …

The formation of blood clots—thrombosis—at sites of atherosclerotic plaque rupture is a
major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in …

Atherosclerosis is the underlying reason for nearly all causes of coronary artery disease and
peripheral arterial disease and many cases of stroke. Atherosclerosis is a systemic …

During the past decade, our understanding of the pathophysiology of coronary artery
disease (CAD) has undergone a remarkable evolution. We review here how these advances …

The Hemostatic System as a Modulator of Atherosclerosis | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …

High dietary fructose is a major contributor to insulin resistance and metabolic syndrome,
disturbing tissue and organ functions. Fructose is mainly absorbed into systemic circulation …

Background—Inflammatory reactions in coronary plaques play an important role in the
pathogenesis of acute atherothrombotic events; inflammation elsewhere is also associated …