The glyoxalase system has been studied since 1913. The biochemical function of this
enzymatic system is the metabolism of reactive dicarbonyl metabolites, glyoxal and …

Glyoxalases are known to play a very important role in abiotic stress tolerance. This two-step
pathway detoxifies ubiquitously present cytotoxic metabolite methylglyoxal, which otherwise …

Metalloproteomics includes approaches that address the expression of metalloproteins and
their changes in biological time and space. Metalloproteomes are investigated by a …

Summary Glyoxalase II (GLY II), the second enzyme of glyoxalase pathway that detoxifies
cytotoxic metabolite methylglyoxal (MG), belongs to the superfamily of metallo‐β …

Glyoxalase 2 is a mitochondrial and cytoplasmic protein belonging to the metallo-β-
lactamase family encoded by the hydroxyacylglutathione hydrolase (HAGH) gene. This …

Immunometabolism is critical in the regulation of immunity and inflammation; however, the
mechanism of preventing aberrant activation-induced immunopathology remains largely …

The mitochondrial pool of GSH (glutathione) is considered the major redox system in
maintaining matrix redox homeostasis, preserving sulfhydryl groups of mitochondrial …

Methylglyoxal (MG) is a reactive and toxic compound produced in carbohydrate, lipid, and
amino acid metabolism. The glyoxalase system is the main detoxifying route for MG and …

The glyoxalase system is composed of two metalloenzymes, Glyoxalase I and Glyoxalase II.
This system is important in the detoxification of methylglyoxal, among other roles. Detailed …

Glyoxalase II (GlxII) is an antioxidant glutathione-dependent enzyme, which catalyzes the
hydrolysis of SD-lactoylglutathione to form D-lactic acid and glutathione (GSH). The last …