Plasmodium falciparum Malaria Vaccines and Vaccine Adjuvants

SR Bonam, L Rénia, G Tadepalli, J Bayry, HMS Kumar - Vaccines, 2021 - mdpi.com
Malaria—a parasite vector-borne disease—is a global health problem, and Plasmodium
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …

Advances in oral subunit vaccine design

H Van der Weken, E Cox, B Devriendt - Vaccines, 2020 - mdpi.com
Many pathogens invade the host at the intestinal surface. To protect against these
enteropathogens, the induction of intestinal secretory IgA (SIgA) responses is paramount …

Pre-erythrocytic vaccines against malaria

C Marques-da-Silva, K Peissig, SP Kurup - Vaccines, 2020 - mdpi.com
Malaria, caused by the protozoan Plasmodium, is a devastating disease with over 200
million new cases reported globally every year. Although immunization is arguably the best …

[HTML][HTML] Carbohydrate-based adjuvants

P Garcia-Vello, I Speciale, F Chiodo, A Molinaro… - Drug Discovery Today …, 2020 - Elsevier
Highlights•Carbohydrate-based adjuvants are safe, biocompatible and capable to stimulate
strong and long-lasting humoral and cellular immune responses.•Lipid A derived …

[HTML][HTML] CRISPR/Cas advancements for genome editing, diagnosis, therapeutics, and vaccine development for Plasmodium parasites, and genetic engineering of …

L Nourani, AA Mehrizi, S Pirahmadi… - Infection, Genetics and …, 2023 - Elsevier
Malaria as vector-borne disease remains important health concern with over 200 million
cases globally. Novel antimalarial medicines and more effective vaccines must be …

GD2-targeting therapy: a comparative analysis of approaches and promising directions

J Philippova, J Shevchenko, S Sennikov - Frontiers in Immunology, 2024 - frontiersin.org
Disialoganglioside GD2 is a promising target for immunotherapy with expression primarily
restricted to neuroectodermal and epithelial tumor cells. Although its role in the maintenance …

Current vaccine approaches and emerging strategies against herpes simplex virus (HSV)

VN Wijesinghe, IA Farouk, NZ Zabidi… - Expert Review of …, 2021 - Taylor & Francis
Introduction Vaccine development for the disease caused by the herpes simplex virus (HSV)
has been challenging over the years and is always in dire need of novel approaches for …

Adjuvants: friends in vaccine formulations against infectious diseases

GG Guerrero Manriquez, I Tuero - Human vaccines & …, 2021 - Taylor & Francis
Infectious diseases represent a major cause of deaths worldwide. No vaccine or effective
treatment exists nowadays, especially against intracellular pathogens. The increase in …

Malaria transmission blocking activity of Anopheles stephensi alanyl aminopeptidase N antigen formulated with MPL, CpG, and QS21 adjuvants

Z Pourhashem, L Nourani, S Pirahmadi, H Yousefi… - Plos one, 2024 - journals.plos.org
Backgrounds Malaria, a preventive and treatable disease, is still responsible for annual
deaths reported in most tropical regions, principally in sub-Saharan Africa. Subunit …

A review of combination adjuvants for malaria vaccines: a promising approach for vaccine development

S Pirahmadi, S Zakeri, ND Djadid, AA Mehrizi - International journal for …, 2021 - Elsevier
It is obvious that there is a critical need for an efficient malaria vaccine to accelerate malaria
eradication. Currently, recombinant subunit vaccination against malaria using proteins and …