Mutation and horizontal gene transfer (HGT) continually give rise to new bacterial
genotypes. Infrequently, such new bacterial genotypes establish and spread in the larger …

Actinobacteria constitute one of the largest phyla among Bacteria and represent gram-
positive bacteria with a high G+ C content in their DNA. This bacterial group includes …

Covering: up to mid-2009 The phylum Actinobacteria hosts diverse high G+ C, Gram-
positive bacteria that have evolved a complex chemical language of natural product …

While the biological functions of most of the secondary metabolites made by streptomycetes
are not known, it is inconceivable that they do not play an adaptive ecological role. The …

Small signalling molecules called γ-butyrolactones are mainly produced by Streptomyces
species in which they regulate antibiotic production and morphological differentiation. Their …

Many of the antibiotics used today are made by a group of bacteria called Streptomyces.
Streptomycetes evolved about 450 million years ago as branched filamentous organisms …

▪ Abstract Recent advances in DNA-sequencing technologies have made available an
enormous resource of data for the study of bacterial genomes. The broad sample of …

Streptomycetes are high G+ C Gram-positive, antibiotic-producing, soil bacteria that undergo
complex morphological differentiation (Chater, 2001). The 8.7 Mb Streptomyces coelicolor …

Abstract The 8–9-Mb Streptomyces chromosome is linear, with a “core” containing essential
genes and “arms” carrying conditionally adaptive genes that can sustain large deletions in …

Plasmids are mobile genetic elements that play a key role in the evolution of bacteria by
mediating genome plasticity and lateral transfer of useful genetic information. Although …