Association between CYP3A4/CYP3A5 genetic polymorphisms and treatment outcomes of atorvastatin worldwide: is there enough research on the Egyptian …
Introduction Atorvastatin is regarded as the most frequently prescribed statin worldwide for
dyslipidemia. However, clinical response and risk of adverse effects to statin therapy are …
dyslipidemia. However, clinical response and risk of adverse effects to statin therapy are …
[HTML][HTML] CYP2D6 overview: allele and phenotype frequencies
M Kane - Medical Genetics Summaries [Internet], 2021 - ncbi.nlm.nih.gov
Genetic variation has a significant impact on an individual's metabolism and response to a
wide range of medications. The cytochrome P450 family of enzymes are key determinants in …
wide range of medications. The cytochrome P450 family of enzymes are key determinants in …
The potential impact of CYP2D6 (* 2/* 4/* 10) gene variants among Egyptian epileptic children: a preliminary study
Abstract Background The cytochrome P450 (CYP) isoenzymes have an indispensable role
in the metabolic phase of different medications during the treatment of multiple …
in the metabolic phase of different medications during the treatment of multiple …
Frequencies of CYP2D6 genetic polymorphisms in Arab populations
CYP2D6 is a key drug-metabolizing enzyme implicated in the biotransformation of
approximately 25% of currently prescribed drugs. Interindividual and interethnic differences …
approximately 25% of currently prescribed drugs. Interindividual and interethnic differences …
Influence of CYP3A4*22 and CYP3A5*3 combined genotypes on tacrolimus dose requirements in Egyptian renal transplant patients
Background Tacrolimus is a widely prescribed immunosuppressant agent for kidney
transplantation. However, optimal dosing is challenging due to its narrow therapeutic index …
transplantation. However, optimal dosing is challenging due to its narrow therapeutic index …
Changes in the pharmacokinetics and pharmacodynamics of sildenafil in cigarette and cannabis smokers
Sildenafil citrate, a widely-used oral therapy for erectile dysfunction, is a cytochrome P3A4
(CYP3A4) enzyme substrate. Studies have reported that this substrate has an inhibitory …
(CYP3A4) enzyme substrate. Studies have reported that this substrate has an inhibitory …
CYP3A4*1B and CYP3A5*3 SNPs significantly impact the response of Egyptian candidates to high-intensity statin therapy to atorvastatin
Background A single nucleotide polymorphism (SNP) is a variation in the DNA sequence
that results from the alteration of a single nucleotide in the genome. Atorvastatin is used to …
that results from the alteration of a single nucleotide in the genome. Atorvastatin is used to …
Effect of CYP3A4* 22, CYP3A5* 3 and POR* 28 genetic polymorphisms on calcineurin inhibitors dose requirements in early phase renal transplant patients
Objective This study aimed to investigate the combined effect of CYP3A5* 3, CYP3A4* 22,
and POR* 28 genetic polymorphisms on tacrolimus and cyclosporine dose requirements …
and POR* 28 genetic polymorphisms on tacrolimus and cyclosporine dose requirements …
Ten Years of Experience Support Pharmacogenetic Testing to Guide Individualized Drug Therapy
MC Peña-Martín, B García-Berrocal, A Sánchez-Martín… - Pharmaceutics, 2022 - mdpi.com
Precision medicine utilizing the genetic information of genes involved in the metabolism and
disposition of drugs can not only improve drug efficacy but also prevent or minimize adverse …
disposition of drugs can not only improve drug efficacy but also prevent or minimize adverse …
PREVALENCE OF CYP2D6* 4 AND ITS POSSIBLE RELATION TO THERAPEUTIC OUTCOMES OF ADJUVANT TAMOXIFEN THERAPY IN EGYPTIAN …
Background: Although tamoxifen is a main adjuvant therapy in estrogen positive breast
cancer especially in premenopausal women, reliance on genetic polymorphisms of its …
cancer especially in premenopausal women, reliance on genetic polymorphisms of its …