Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Progression in translational research on spinal cord injury based on microenvironment imbalance

B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

Traumatic spinal cord injury

CS Ahuja, JR Wilson, S Nori, M Kotter… - Nature reviews Disease …, 2017 - nature.com
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and
vocational well-being of patients. The demographic of SCIs is shifting such that an …

Time is spine: a review of translational advances in spinal cord injury: JNSPG 75th Anniversary Invited Review Article

JH Badhiwala, CS Ahuja, MG Fehlings - Journal of Neurosurgery: Spine, 2018 - thejns.org
Acute traumatic spinal cord injury (SCI) is a devastating event with far-reaching physical,
emotional, and economic consequences for patients, families, and society at large. Timely …

First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol

K Sugai, M Sumida, T Shofuda, R Yamaguchi… - Regenerative …, 2021 - Elsevier
Introduction Our group has conducted extensive basic and preclinical studies of the use of
human induced pluripotent cell (iPSC)-derived neural stem/progenitor cell (hiPSC-NS/PC) …

Assessment and management of acute spinal cord injury: From point of injury to rehabilitation

LD Hachem, CS Ahuja, MG Fehlings - The journal of spinal cord …, 2017 - Taylor & Francis
Context: Spinal cord injury (SCI) is a devastating condition that can lead to significant
neurological impairment and reduced quality of life. Despite advancements in our …

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Restoring function after spinal cord injury: towards clinical translation of experimental strategies

LM Ramer, MS Ramer, EJ Bradbury - The Lancet Neurology, 2014 - thelancet.com
Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

Pathophysiology and therapeutic approaches for spinal cord injury

R Lima, A Monteiro, AJ Salgado, S Monteiro… - International Journal of …, 2022 - mdpi.com
Spinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic
functions. Despite extensive research in the last decades, SCI continues to be a global …

Acute spinal cord injury

CD Witiw, MG Fehlings - Clinical Spine Surgery, 2015 - journals.lww.com
Our understanding of the pathophysiological processes that comprise the early secondary
phases of spinal cord injury such as spinal cord ischemia, cellular excitotoxicity, ionic …