Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
Genetic–epigenetic interactions in cis: a major focus in the post-GWAS era
Studies on genetic–epigenetic interactions, including the mapping of methylation
quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation …
quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation …
Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
Identifying methylation quantitative trait loci (meQTLs) and integrating them with disease-
associated variants from genome-wide association studies (GWAS) may illuminate …
associated variants from genome-wide association studies (GWAS) may illuminate …
[HTML][HTML] Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A
CQ Lai, LD Parnell, CE Smith, T Guo… - The American journal of …, 2020 - Elsevier
Background Epigenome-wide association studies identified the cg00574958 DNA
methylation site at the carnitine palmitoyltransferase-1A (CPT1A) gene to be associated with …
methylation site at the carnitine palmitoyltransferase-1A (CPT1A) gene to be associated with …
[HTML][HTML] Transgenerational and intergenerational epigenetic inheritance in allergic diseases
It has become clear that early life (including in utero exposures) is a key window of
vulnerability during which environmental exposures can alter developmental trajectories …
vulnerability during which environmental exposures can alter developmental trajectories …
[HTML][HTML] Frailty and biological age
L Ji, SM Jazwinski, S Kim - Annals of geriatric medicine and …, 2021 - ncbi.nlm.nih.gov
A reliable model of biological age is instrumental in the field of geriatrics and gerontology.
This model should account for the heterogeneity and plasticity of aging and also accurately …
This model should account for the heterogeneity and plasticity of aging and also accurately …
Association of methylation signals with incident coronary heart disease in an epigenome-wide assessment of circulating tumor necrosis factor α
Importance Tumor necrosis factor α (TNF-α) is a proinflammatory cytokine with manifold
consequences for mammalian pathophysiology, including cardiovascular disease. A deeper …
consequences for mammalian pathophysiology, including cardiovascular disease. A deeper …
IMAGE: high-powered detection of genetic effects on DNA methylation using integrated methylation QTL mapping and allele-specific analysis
Identifying genetic variants that are associated with methylation variation—an analysis
commonly referred to as methylation quantitative trait locus (mQTL) mapping—is important …
commonly referred to as methylation quantitative trait locus (mQTL) mapping—is important …
Breast cancer family history and allele-specific DNA methylation in the legacy girls study
HC Wu, C Do, IL Andrulis, EM John, MB Daly… - Epigenetics, 2018 - Taylor & Francis
Family history, a well-established risk factor for breast cancer, can have both genetic and
environmental contributions. Shared environment in families as well as epigenetic changes …
environmental contributions. Shared environment in families as well as epigenetic changes …
Testing two evolutionary theories of human aging with DNA methylation data
The evolutionary theories of mutation accumulation (MA) and disposable soma (DS) provide
possible explanations for the existence of human aging. To better understand the relative …
possible explanations for the existence of human aging. To better understand the relative …