Pathophysiology of blood–brain barrier permeability throughout the different stages of ischemic stroke and its implication on hemorrhagic transformation and recovery

S Bernardo-Castro, JA Sousa, A Brás, C Cecília… - Frontiers in …, 2020 - frontiersin.org
The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining the central
nervous system homeostasis. Its unique characteristics allow protecting the brain from …

Blood-brain barrier dysfunction and recovery after ischemic stroke

X Jiang, AV Andjelkovic, L Zhu, T Yang… - Progress in …, 2018 - Elsevier
The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

Impact of an immune modulator fingolimod on acute ischemic stroke

Y Fu, N Zhang, LI Ren, Y Yan, N Sun… - Proceedings of the …, 2014 - National Acad Sciences
Peripheral lymphocytes entering brain ischemic regions orchestrate inflammatory
responses, catalyze tissue death, and worsen clinical outcomes of acute ischemic stroke …

Evolution of blood-brain-barrier permeability after acute ischemic stroke

Z Merali, K Huang, D Mikulis, F Silver, A Kassner - PloS one, 2017 - journals.plos.org
The dynamics of BBB permeability after AIS in humans are not well understood. In the
present study we measured the evolution of BBB permeability after AIS in humans using …

Blood–brain barrier disruption and hemorrhagic transformation in acute ischemic stroke: systematic review and meta-analysis

F Arba, C Rinaldi, D Caimano, F Vit, G Busto… - Frontiers in …, 2021 - frontiersin.org
Introduction: Hemorrhagic transformation (HT) is a complication of reperfusion therapy for
acute ischemic stroke. Blood–brain barrier (BBB) disruption is a crucial step toward HT; …

Time-dependent dual effect of microglia in ischemic stroke

P Fan, S Wang, S Chu, N Chen - Neurochemistry international, 2023 - Elsevier
Stroke, the third leading cause of death and disability worldwide, is classified into ischemic
or hemorrhagic, in which approximately 85% of strokes are ischemic. Ischemic stroke occurs …

The evolution of blood–brain barrier permeability changes after stroke and its implications on clinical outcome: A systematic review and meta-analysis

S Bernardo-Castro, JA Sousa… - … Journal of Stroke, 2023 - journals.sagepub.com
Background: Blood–brain barrier permeability (BBBp) is a key process involved in ischemic
stroke pathophysiology. However, there is a lack of consensus on how BBBp evolves after …

Clinical biomarkers differentiate myelitis from vascular and other causes of myelopathy

P Barreras, KC Fitzgerald, MA Mealy, JA Jimenez… - Neurology, 2018 - AAN Enterprises
Objective To assess the predictive value of the initial clinical and paraclinical features in the
differentiation of inflammatory myelopathies from other causes of myelopathy in patients with …

DCE-MRI blood–brain barrier assessment in acute ischemic stroke

K Villringer, BE Sanz Cuesta, AC Ostwaldt, U Grittner… - Neurology, 2017 - AAN Enterprises
Objective: To quantitatively evaluate blood–brain barrier changes in ischemic stroke patients
using dynamic contrast-enhanced (DCE) MRI. Methods: We examined 54 stroke patients …

Aerobic training and mobilization early post-stroke: cautions and considerations

S Marzolini, AD Robertson, P Oh, JM Goodman… - Frontiers in …, 2019 - frontiersin.org
Knowledge gaps exist in how we implement aerobic exercise programs during the early
phases post-stroke. Therefore, the objective of this review was to provide evidence-based …