Biomaterial-assisted macrophage cell therapy for regenerative medicine

S Sung, LA Steele, GE Risser, KL Spiller - Advanced drug delivery reviews, 2023 - Elsevier
Although most tissue types are capable of some form of self-repair and regeneration, injuries
that are larger than a critical threshold or those occurring in the setting of certain diseases …

Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives

GF Vasse, M Nizamoglu, IH Heijink… - The Journal of …, 2021 - Wiley Online Library
Fibrosis results from aberrant wound healing and is characterized by an accumulation of
extracellular matrix, impairing the function of an affected organ. Increased deposition of …

Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages

CE Witherel, K Sao, BK Brisson, B Han, SW Volk… - Biomaterials, 2021 - Elsevier
Aberrant extracellular matrix (ECM) assembly surrounding implanted biomaterials is the
hallmark of the foreign body response, in which implants become encapsulated in thick …

Delivery of a spheroids-incorporated human dermal fibroblast sheet increases angiogenesis and M2 polarization for wound healing

SW Kim, GB Im, GJ Jeong, S Baik, J Hyun, YJ Kim… - Biomaterials, 2021 - Elsevier
Low cell engraftment is a major problem in tissue engineering. Although various methods
related with cell sheets have been attempted to resolve the issue, low cell viability due to …

Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy

Y Xu, L Ying, JK Lang, B Hinz, R Zhao - Science Advances, 2024 - science.org
Pulmonary fibrosis is an often fatal lung disease. Immune cells such as macrophages were
shown to accumulate in the fibrotic lung, but their contribution to the fibrosis development is …

Nano drug delivery systems: a promising approach to scar prevention and treatment

JY Ding, L Sun, ZH Zhu, XC Wu, XL Xu… - Journal of …, 2023 - Springer
Scar formation is a common physiological process that occurs after injury, but in some
cases, pathological scars can develop, leading to serious physiological and psychological …

Fabrication of PNIPAm-based thermoresponsive hydrogel microwell arrays for tumor spheroid formation

D Dhamecha, D Le, T Chakravarty, K Perera… - Materials Science and …, 2021 - Elsevier
Abstract Complex three-dimensional (3D) cell cultures are being increasingly implemented
in biomedical research as they provide important insights into complex cancer biology, and …

Multifunctional carbon dots originated from waste garlic peel for rapid sensing of heavy metals and fluorescent imaging of 2D and 3D spheroids cultured fibroblast …

P Krishnaiah, R Atchudan, S Perumal… - … Acta Part A: Molecular …, 2024 - Elsevier
Here, we prepared sulfur and nitrogen self-doped carbon dots derived from garlic peel
extract (GPSNCDs) using a hydrothermal method. The as-synthesized GPSNCDs were …

Microfluidic arrays of dermal spheroids: A screening platform for active ingredients of skincare products

Z Chen, S Kheiri, A Gevorkian, EWK Young, V Andre… - Lab on a Chip, 2021 - pubs.rsc.org
Organotypic micrometre-size 3D aggregates of skin cells (multicellular spheroids) have
emerged as a promising in vitro model that can be utilized as an alternative of animal …

Engineering advanced in vitro models of systemic sclerosis for drug discovery and development

A De Pieri, BD Korman, A Jüngel… - Advanced …, 2021 - Wiley Online Library
Systemic sclerosis (SSc) is a complex multisystem disease with the highest case‐specific
mortality among all autoimmune rheumatic diseases, yet without any available curative …