All endocrine glands are susceptible to neoplastic growth, yet the health consequences of
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …

The transcription factor SOX2 is essential for embryonic development and plays a crucial
role in maintaining the stemness of embryonic cells and various adult stem cell populations …

Sox family transcription factors are well-established regulators of cell fate decisions during
development. Accumulating evidence documents that they play additional roles in adult …

The transcription factor Sox2 maintains the pluripotency of early embryonic cells and
regulates the formation of several epithelia during fetal development. Whether Sox2 …

Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

Controversy surrounds reports describing the derivation of human trophoblast cells from
placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers …

Sox2+ adult mouse pituitary cells can self-renew and terminally differentiate in vitro, but their
physiological role in vivo and possible contribution to oncogenesis remain largely unknown …

Pituitary adenomas may hypersecrete hormones (including prolactin, growth hormone and
adrenocorticotropic hormone, and rarely follicle-stimulating hormone, luteinizing hormone or …

Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

Transcription factors and signaling pathways that regulate stem cells and specialized
hormone-producing cells in the pituitary gland have been the subject of intense study and …