[HTML][HTML] Retinitis pigmentosa: novel therapeutic targets and drug development

KY Wu, M Kulbay, D Toameh, AQ Xu, A Kalevar… - Pharmaceutics, 2023 - mdpi.com
Retinitis pigmentosa (RP) is a heterogeneous group of hereditary diseases characterized by
progressive degeneration of retinal photoreceptors leading to progressive visual decline. It …

MAPK pathways in ocular pathophysiology: potential therapeutic drugs and challenges

P Moustardas, D Aberdam, N Lagali - Cells, 2023 - mdpi.com
Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous cellular signal
transduction pathways that regulate all aspects of life and are frequently altered in disease …

Role of transforming growth factor-β in peripheral nerve regeneration

Z Ding, M Jiang, J Qian, D Gu, H Bai… - Neural Regeneration …, 2023 - journals.lww.com
Injuries caused by trauma and neurodegenerative diseases can damage the peripheral
nervous system and cause functional deficits. Unlike in the central nervous system …

Role of transforming growth factor beta in peripheral nerve regeneration: cellular and molecular mechanisms

Z Ye, J Wei, C Zhan, J Hou - Frontiers in Neuroscience, 2022 - frontiersin.org
Peripheral nerve injury (PNI) is one of the most common concerns in trauma patients.
Despite significant advances in repair surgeries, the outcome can still be unsatisfactory …

Identification and comprehensive analysis of ferroptosis-related genes as potential biomarkers for the diagnosis and treatment of proliferative diabetic retinopathy by …

D Cao, C Wang, L Zhou - Experimental Eye Research, 2023 - Elsevier
Diabetic retinopathy (DR) is the most common retinal vascular disease. Proliferative DR
(PDR) is the aggressive stage of DR with angiogenesis as a pathological hallmark, which is …

Non-apoptotic programmed cell death as targets for diabetic retinal neurodegeneration

Y Lin, S Ke, W Ye, B Xie, Z Huang - Pharmaceuticals, 2024 - mdpi.com
Diabetic retinopathy (DR) remains the leading cause of blindness among the global working-
age population. Emerging evidence underscores the significance of diabetic retinal …

Immunology of Retinitis Pigmentosa and Gene Therapy–Associated Uveitis

P Yang, D Mustafi, KL Pepple - Cold Spring Harbor …, 2024 - pmc.ncbi.nlm.nih.gov
The underlying immune state of inherited retinal degenerations (IRDs) and retinitis
pigmentosa (RP) has been an emerging area of interest, where in the consequences have …

Weighted gene co-expression network analysis to identify ferroptosis-related hub genes and their potential ceRNA networks in diabetic retinopathy

K Chen, X Wang, S Qu, Z Wang, Y Shao, GT Xu… - Experimental Eye …, 2023 - Elsevier
Diabetic retinopathy (DR) is a common blinding complication in patients with type I and type
II diabetes mellitus (Graham et al., 2018). DR is a progressive retinal vascular damage …

Pax6 expressing neuroectodermal and ocular stem cells: Its role from a developmental biology perspective

S More, S Mallick, SS P, B Bose - Cell Biology International, 2024 - Wiley Online Library
Pax‐6 emerges as a critical transcription factor that guides the fate of stem cells towards
neural lineages. Its expression influences the differentiation of neural progenitors into …

Transcriptome sequencing reveals Tgf-β-mediated noncoding RNA regulatory mechanisms involved in DNA damage in the 661W photoreceptor cell line

Y Huang, X Chen, Z Jiang, Q Luo, L Wan, X Hou, K Yu… - Genes, 2022 - mdpi.com
Transforming growth factor β (Tgf-β), a pleiotropic cytokine, can enhance DNA repair in
various cells, including cancer cells and neurons. The noncoding regulatory system plays an …