For the past two decades, cellular senescence has been recognized as a central component
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …

Cellular senescence is a stress response elicited by different molecular insults. Senescence
results in cell cycle exit and is characterised by multiple phenotypic changes such as the …

Inhibition of the cell-cycle kinases CDK4 and CDK6 is now part of the standard treatment in
advanced breast cancer. CDK4/6 inhibitors, however, are not expected to cooperate with …

E2F transcription factors play critical roles in the cell cycle. Therefore, their activity is
expected to reflect tumor aggressiveness and responsiveness to therapy. We scored 3905 …

Great progress has been made in the field of tumor immunotherapy in the past decade.
However, the therapeutic effects of immune checkpoint blockade (ICB) against ovarian …

Abstract Therapy-Induced Senescence (TIS) is an established response to anticancer
therapy in a variety of cancer models. Ample evidence has characterized the triggers …

Tumors arise from the transformation of normal stem cells or mature somatic cells.
Intriguingly, two types of tumors have been observed by pathologists for centuries: well …

The promising antitumor effects of progesterone derivatives have been identified in many
studies. However, the specific mechanism of action of this class of compounds has not been …

The cyclin D-CDK4/6 complexes play a pivotal role in controlling the cell cycle. Deregulation
in cyclin D-CDK4/6 pathway has been described in many types of cancer and it invariably …

Hydroxyurea (HU) is a water‐soluble antiproliferative agent used for decades in neoplastic
and nonneoplastic conditions. HU is considered an essential medicine because of its …