Matrix‐dependent signal suppression or enhancement represents a major drawback in
quantitative analysis with liquid chromatography coupled to atmospheric pressure ionization …

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has seen enormous growth
in clinical laboratories during the last 10–15 years. It offers analytical specificity superior to …

Although, LC–MS is one of the most sensitive and selective analytical techniques, it often
suffers from matrix effects, especially when using ESI for analyzing extracts of complicated …

Liquid chromatography coupled to atmospheric pressure ionization tandem mass
spectrometry is currently the method of choice for the quantitative determination of drugs in …

Matrix effects can significantly impede the accuracy, sensitivity, and reliability of separation
techniques presenting a formidable challenge to the analytical process. It is crucial to …

A systematic, comprehensive strategy that optimizes sample preparation and
chromatography to minimize matrix effects in bioanalytical LC/MS/MS assays was …

Liquid chromatography-mass spectrometry analysis of small molecules from biofluids
requires sensitive and robust assays. Because of the very complex nature of many biological …

Ceramides (CERs) in the upper layer of the skin, the stratum corneum (SC), play a key role
in the skin barrier function. In human SC, the literature currently reports 11 CER subclasses …

Per and polyfluoroalkyl substances (PFAS) are a group of man-made chemicals
characterized by their ubiquitous nature in all environmental compartments which makes …

Human meibomian gland secretions (MGS, or meibum) are formed from a complex mixture
of lipids of different classes such as wax esters, cholesteryl esters,(O-acyl)-ω-hydroxy fatty …