Biotechnology approaches for natural product discovery, engineering, and production based on Burkholderia bacteria

BI Adaikpoh, HN Fernandez, AS Eustáquio - Current opinion in …, 2022 - Elsevier
Highlights•Approaches used include RecET recombination, CRISPR–Cas9, and transposon
mutagenesis.•RecET-like recombinases and CRISPR–Cas systems were identified in …

Bacterial extracellular vesicles: modulation of biofilm formation and virulence

GJ Jeong, F Khan, N Tabassum, KJ Cho, YM Kim - Acta Biomaterialia, 2024 - Elsevier
Microbial pathogens cause persistent infections by forming biofilms and producing
numerous virulence factors. Bacterial extracellular vesicles (BEVs) are nanostructures …

Economical Di-Rhamnolipids Biosynthesis by Non-Pathogenic Burkholderia thailandensis E264 Using Post-Consumption Food Waste in a Biorefinery Approach

R Kumar, D Johnravindar, JWC Wong, RD Patria… - Sustainability, 2022 - mdpi.com
Rhamnolipids (RLs) are one of the most promising eco-friendly green alternatives to
commercially viable fossil fuel-based surfactants. However, the current bioprocess practices …

Secondary metabolites from the Burkholderia pseudomallei complex: structure, ecology, and evolution

JR Klaus, PML Coulon, P Koirala… - Journal of Industrial …, 2020 - academic.oup.com
Bacterial secondary metabolites play important roles in promoting survival, though few have
been carefully studied in their natural context. Numerous gene clusters code for secondary …

[HTML][HTML] Sustainable rhamnolipids production in the next decade–advancing with Burkholderia thailandensis as a potent biocatalytic strain

R Kumar, RI Barbhuiya, V Bohra, JWC Wong… - Microbiological …, 2023 - Elsevier
Rhamnolipids are one of the most promising eco-friendly green glycolipids for bio-
replacements of commercially available fossil fuel-based surfactants. However, the current …

Lactonase-mediated inhibition of quorum sensing largely alters phenotypes, proteome, and antimicrobial activities in Burkholderia thailandensis E264

M Gonzales, L Plener, J Armengaud… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Burkholderia thailandensis is a study model for Burkholderia pseudomallei, a
highly virulent pathogen, known to be the causative agent of melioidosis and a potential …

Burkholderia pseudomallei produces 2-alkylquinolone derivatives important for host virulence and competition with bacteria that employ naphthoquinones for aerobic …

S Mou, V Savchenko, V Filz, T Böttcher… - Frontiers in …, 2024 - frontiersin.org
Melioidosis is caused by Burkholderia pseudomallei, an opportunistic Gram-negative
pathogen that inhabits soil and water in tropical and subtropical regions. B. pseudomallei …

Metabolomics Analysis of Bacterial Pathogen Burkholderia thailandensis and Mammalian Host Cells in Co-culture

N Aiosa, A Sinha, OA Jaiyesimi… - ACS Infectious …, 2022 - ACS Publications
The Tier 1 HHS/USDA Select Agent Burkholderia pseudomallei is a bacterial pathogen that
is highly virulent when introduced into the respiratory tract and intrinsically resistant to many …

The Burkholderia pseudomallei hmqA-G Locus Mediates Competitive Fitness against Environmental Gram-Positive Bacteria

S Mou, CC Jenkins, U Okaro… - Microbiology …, 2021 - Am Soc Microbiol
Burkholderia pseudomallei is an opportunistic pathogen that is responsible for the disease
melioidosis in humans and animals. The microbe is a tier 1 select agent because it is highly …

Whole‐Cell MALDI‐ToF MS Coupled with Untargeted Metabolomics Facilitates Investigations of Microbial Chemical Interactions

N Aiosa, A Sinha, H Albataineh, AM Phillips… - …, 2023 - Wiley Online Library
The emergence of drug‐resistant pathogens necessitates the development of new
countermeasures. In this regard, the introduction of probiotics to directly attack or …