Environmental toxins and Parkinson's disease

SM Goldman - Annual review of pharmacology and toxicology, 2014 - annualreviews.org
Parkinson's disease (PD) is a chronic, progressive, disabling neurodegenerative disorder
that begins in mid to late life and is characterized by motor impairment, autonomic …

Mitochondrial dysfunction in Parkinson′ s disease

PC Keane, M Kurzawa, PG Blain… - Parkinson's …, 2011 - Wiley Online Library
Parkinson′ s disease (PD) is a progressive, neurodegenerative condition that has
increasingly been linked with mitochondrial dysfunction and inhibition of the electron …

Solvent exposures and Parkinson disease risk in twins

SM Goldman, PJ Quinlan, GW Ross… - Annals of …, 2012 - Wiley Online Library
Objective: Several case reports have linked solvent exposure to Parkinson disease (PD), but
few studies have assessed associations with specific agents using an analytic …

[图书][B] Die Parkinson-Krankheit: Grundlagen, Klinik, Therapie

M Gerlach, H Reichmann, P Riederer - 2007 - books.google.com
Dieses Buch vermittelt einen kompetenten und fächerübergreifenden Überblick über das
aktuelle Wissen auf dem Gebiet der Parkinson-Krankheit. Es ist im deutschsprachigen …

Indole derivatives as neuroprotectants

S Štolc - Life sciences, 1999 - Elsevier
It seems to be satisfactorily proved that reactive oxygen species (ROS) participate in
numerous pathological processes in the nervous system (NS). Compounds able to interfere …

Potential metabolic bioactivation pathways involving cyclic tertiary amines and azaarenes

N Castagnoli, JM Rimoldi, J Bloomquist… - Chemical research in …, 1997 - ACS Publications
This review focuses on the biotransformation of cyclic tertiary amines and selected
azaarenes to potentially toxic metabolites. Special emphasis will be placed on 6-membered …

Biochemical and pharmacological characterization of 1-trichloromethyl-1, 2, 3, 4-tetrahydro-β-carboline: a biologically relevant neurotoxin?

P Riederer, P Foley, G Bringmann, D Feineis… - European Journal of …, 2002 - Elsevier
Acute and long-term effects of exposure to reactive compounds as the result of
environmental pollution, workplace conditions or dietary intake are suspected to be involved …

Connecting the dots between mitochondrial dysfunction and Parkinson's disorder: Focus mitochondria-targeting therapeutic paradigm in mitigating the disease …

I Kaur, T Behl, A Sehgal, S Singh, N Sharma… - … Science and Pollution …, 2021 - Springer
Mitochondria are unique cell organelles, which exhibit multifactorial roles in numerous cell
physiological processes, significantly preserving the integrity of neural synaptic …

[HTML][HTML] Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α …

PC Keane, PS Hanson, L Patterson, PG Blain… - Neuroscience …, 2019 - Elsevier
Parkinson's disease (PD) is characterised pathologically by degeneration of the
dopaminergic (DA) neurones of the substantia nigra pars compacta (SNpc) and the …

The endogeneous formation of highly chlorinated tetrahydro-ß-carbolines as a possible causative mechanism in idiopathic Parkinson's disease

W Kochen, D Kohlmüller, P De Biasi… - … in Tryptophan and …, 2003 - Springer
The causative interrelationship between long-term, low level exposure to chlorinated volatile
organic solvents (VOSs) and neurodegenerative diseases (polyneuropathy …