Mitochondria tailor their morphology to execute their specialized functions in different cell
types and/or different environments. During spermatogenesis, mitochondria undergo …

Infertility is a global health problem affecting one in six couples, with 50% of cases attributed
to male infertility. Spermatozoa are male gametes, specialized cells that can be divided into …

Calcineurin is a calcium-dependent phosphatase that plays roles in a variety of biological
processes including immune responses. In spermatozoa, there is a testis-enriched …

Spermatozoa need to undergo an exocytotic event called the acrosome reaction before
fusing with eggs. Although calcium ion (Ca2+) is essential for the acrosome reaction, its …

Although several long noncoding RNAs (lncRNAs) have recently been shown to encode
small polypeptides, those in testis remain largely uncharacterized. Here we identify two …

Mitochondria–cytoskeleton interactions modulate cellular physiology by regulating
mitochondrial transport, positioning, and immobilization. However, there is very little …

The acrosome is a cap-shaped, Golgi-derived membranous organelle that is located over
the anterior of the sperm nucleus and highly conserved throughout evolution. Although …

Infertility afflicts up to 15% of couples globally each year with men a contributing factor in
50% of these cases. Globozoospermia is a rare condition found in infertile men, which is …

This review summarizes the advancements over a decade of research on antigens of anti-
sperm antibodies (ASAs), which are key to male immune infertility. Despite the progress in …

Spermatozoa have a streamlined shape to swim through the oviduct to fertilize oocytes. To
become svelte spermatozoa, spermatid cytoplasm must be eliminated in several steps …