Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Ribonucleoprotein (RNP) granules are diverse membrane-less organelles that form through
multivalent RNA-RNA, RNA-protein, and protein-protein interactions between RNPs. RNP …

Alphaviruses are a large group of re-emerging arthropod-borne RNA viruses. The compact
viral RNA genomes harbor diverse structures that facilitate replication. These structures can …

RNA-dependent DEAD-box ATPases (DDXs) are emerging as major regulators of RNA-
containing membrane-less organelles (MLOs). On the one hand, oligomerizing DDXs can …

Triple-negative breast cancer (TNBC) is a heterogeneous breast cancer subtype and
accounts for approximately 15–20% of breast cancer cases. In this study, we identified …

Mutations in the RNA helicase DDX3X, implicated in various cancers and
neurodevelopmental disorders, often impair RNA unwinding and translation. However, the …

The second most common male cancer is prostate cancer (PCa), which has a high tendency
for bone metastasis. Long non-coding RNAs, including TMPO-AS1, play a crucial role in …

The complexity of biological sex differences is markedly evident in human physiology and
pathology. Although many of these differences can be ascribed to the expression of sex …

DEAD-and DExH-box ATPases (DDX/DHXs) are abundant and highly conserved cellular
enzymes ubiquitously involved in RNA processing. By remodeling RNA–RNA and RNA …

ABSTRACT RNA helicases are integral in RNA metabolism, performing important roles in
cellular homeostasis and stress responses. In particular, the DExD/H-box (DDX) helicase …