Apoptosis is a form of programmed cell death that results in the orderly and efficient removal
of damaged cells, such as those resulting from DNA damage or during development …

Caspase-8 is a cysteine-aspartate specific protease that classically triggers the extrinsic
apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like …

The innate immune system initiates cell death pathways in response to pathogens and
cellular stress. Cell death can be either non-lytic (apoptosis) or lytic (PANoptosis, pyroptosis …

Targeting apoptosis for the treatment of cancer has become an increasingly attractive
strategy, with agents in development to trigger extrinsic apoptosis via TRAIL signalling, or to …

Pharmacological targeting via small molecule-based chemical probes has recently acquired
an emerging importance as a valuable tool to delineate molecular mechanisms. Induction of …

C-terminal Src kinase (CSK) is a cytosolic tyrosine-protein kinase with an important role in
regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation …

Breast cancer is the most frequent cancer in women worldwide, and drug resistance is
common in all breast cancer types. The combination of natural products with …

Caspases are a family of proteolytic enzymes that play a critical role in the regulation of
programmed cell death via apoptosis. Activation of caspases is frequently impaired in …

Multiple mechanisms of cell death exist (apoptosis, necroptosis, pyroptosis) and the subtle
balance of several distinct proteins and inhibitors tightly regulates the cell fate toward one or …

Background/Aims: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a
potential anti-cancer agent due to its selective toxicity. However, many human non-small cell …