Autophagy as a molecular target for cancer treatment
Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …
[HTML][HTML] Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management
Ultraviolet B (UVB), in addition to having carcinogenic activity, is required for the production
of vitamin D3 (D3) in the skin which supplies> 90% of the body's requirement. Vitamin D is …
of vitamin D3 (D3) in the skin which supplies> 90% of the body's requirement. Vitamin D is …
[HTML][HTML] Active ingredients from Chinese medicine for combination cancer therapy
X Wang, J Li, R Chen, T Li, M Chen - International Journal of …, 2023 - ncbi.nlm.nih.gov
Combination therapy against cancer has gained increasing attention because it can help to
target multiple pathways to tackle oncologic progression and improve the limited antitumor …
target multiple pathways to tackle oncologic progression and improve the limited antitumor …
A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089
K Sharma, RW Goehe, X Di, MA Hicks, SV Torti… - Autophagy, 2014 - Taylor & Francis
The standard of care for unresectable lung cancer is chemoradiation. However, therapeutic
options are limited and patients are rarely cured. We have previously shown that vitamin D …
options are limited and patients are rarely cured. We have previously shown that vitamin D …
[HTML][HTML] Targeting protein kinase A in cancer therapy: an update
L Sapio, F Di Maiolo, M Illiano, A Esposito, E Chiosi… - EXCLI …, 2014 - ncbi.nlm.nih.gov
Abstract Protein Kinase A (PKA) is a well known member of the serine-threonin protein
kinase superfamily. PKA, also known as cAMP-dependent protein kinase, is a multi-unit …
kinase superfamily. PKA, also known as cAMP-dependent protein kinase, is a multi-unit …
The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures
RS Narayan, CA Fedrigo, E Brands, R Dik… - BMC cancer, 2017 - Springer
Background Glioblastoma multiforme (GBM) is the most common, invasive and deadly
primary type of malignant brain tumor. The Phosphatidylinositol-3-Kinase/AKT (PI3K/AKT) …
primary type of malignant brain tumor. The Phosphatidylinositol-3-Kinase/AKT (PI3K/AKT) …
[HTML][HTML] SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human …
Glioblastoma multiforme (GBM) is the most aggressive CNS tumor and is characterized by a
very high frequency of clinical relapse after therapy and thus by a dismal prognosis, which …
very high frequency of clinical relapse after therapy and thus by a dismal prognosis, which …
[HTML][HTML] MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway
S Gao, Z Zhao, R Wu, L Wu, X Tian, Z Zhang - Aging (Albany NY), 2018 - ncbi.nlm.nih.gov
Prostate cancer (PCa) is considered as a common visceral cancer in males and the sixth
major cause of cancer-related deaths in males worldwide. Significant diagnostic and …
major cause of cancer-related deaths in males worldwide. Significant diagnostic and …
High mobility group box 1 promotes radioresistance in esophageal squamous cell carcinoma cell lines by modulating autophagy
H Ma, S Zheng, X Zhang, T Gong, X Lv, S Fu… - Cell Death & …, 2019 - nature.com
Resistance to radiotherapy results in relapse and treatment failure in locally advanced
esophageal squamous cell carcinoma (ESCC). High mobility group box 1 (HMGB1) is …
esophageal squamous cell carcinoma (ESCC). High mobility group box 1 (HMGB1) is …
The autophagic response to radiation: relevance for radiation sensitization in cancer therapy
DA Gewirtz - Radiation research, 2014 - meridian.allenpress.com
Radiation almost uniformly promotes autophagy in tumor cells. While radiation-induced
autophagy often serves as a protective function in cell culture studies, it is currently uncertain …
autophagy often serves as a protective function in cell culture studies, it is currently uncertain …