Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple
organ systems due to an inactivating variant in either TSC1 or TSC2, resulting in the …

Dysregulation of neural stem cells (NSCs) is associated with several neurodevelopmental
disorders, including epilepsy and autism spectrum disorder. The mammalian target of …

The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe
clinical birth defects, particularly microcephaly, warranting urgent study of the molecular …

Non-small cell lung carcinoma (NSCLC) is the most common malignancy worldwide. The
signaling cascades are stimulated via genetic modifications in upstream signaling …

Starting with the outbreak in Brazil, Zika virus (ZIKV) infection has been correlated with
severe syndromes such as congenital Zika syndrome and Guillain‐Barré syndrome. Here …

Insulin‐like growth factor‐I (IGF‐I) signaling plays a key role in neuroinflammation. Here we
show that IGF‐1 also regulates phagocytosis of reactive astrocytes through p110α isoform of …

Abstract Background Disruptions of SETBP1 (SET binding protein 1) on 18q12. 3 by
heterozygous gene deletion or loss-of-function variants cause SETBP1 disorder. Clinical …

Hypoxia-inducible factor (HIF) is a master regulator of cellular responses to oxygen deprival
with a critical role in mediating the angiogenic switch in solid tumors. Differential expression …

The kinase mammalian target of rapamycin (mTOR) integrates signals triggered by energy,
stress, oxygen levels, and growth factors. It regulates ribosome biogenesis, mRNA …

Zika virus (ZIKV) has recently emerged as a new public health threat. ZIKV infections have
caused a wide spectrum of neurological diseases, such as Guillain–Barré syndrome …