GABAA (γ-aminobutyric acid, type A) receptors are a family of ligand-gated ion channels that
are essential for the regulation of central nervous system function. Benzodiazepines—which …

Autism spectrum disorders (ASDs) are neurodevelopmental syndromes characterised by
repetitive behaviours and restricted interests, impairments in social behaviour and relations …

Benzodiazepines have been in use for over half a century. While they remain highly
prescribed, their unfavorable side-effect profile and abuse liability motivated a search for …

Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce
muscle relaxation, control epileptic seizures, and can produce amnesia. Moreover …

Benzodiazepines are widely used in clinics and for recreational purposes, but will lead to
addiction in vulnerable individuals. Addictive drugs increase the levels of dopamine and …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Despite decades of basic and clinical research, our understanding of how benzodiazepines
tend to lose their efficacy over time (tolerance) is at least incomplete. In appears that …

Benzodiazepines (BZDs) are a class of widely prescribed psychotropic drugs that target
GABAA receptors (GABAARs) to tune inhibitory synaptic signaling throughout the central …

Publisher Summary This chapter describes the structure, pharmacology, and function of γ‐
aminobutyric acid type A (GABA A) receptor subtypes. GABA A receptors are the most …

It has recently become more clearly understood that in human brain pathophysiology,
neurosteroids play a role in anxiety disorders, premenstrual syndrome, postpartum …