Germ cell formation and embryonic development require ATP synthesized by mitochondria.
The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are …

Mitochondria tailor their morphology to execute their specialized functions in different cell
types and/or different environments. During spermatogenesis, mitochondria undergo …

Abstract Background Spermatogonial stem cells (SSCs) provide a foundation for robust and
continual spermatogenesis in mammals. SSCs self-renew to maintain a functional stem cell …

The classic roles of mitochondria in energy production, metabolism, and apoptosis have
been well defined. However, a growing body of evidence suggests that mitochondria are …

A bioenergetic balance between glycolysis and mitochondrial respiration is particularly
important for stem cell fate specification. It however remains to be determined whether …

Simple Summary The in vitro maturation (IVM) of oocytes is often delayed due to oxidative
stress and mitochondrial function, resulting in a decrease in oocyte quality. We used a …

Male germline development involves choreographed changes to mitochondrial number,
morphology and organization. Mitochondrial reorganization during spermatogenesis was …

Mitochondria are double membrane-bound organelles the network morphology of which in
cells is shaped by opposing events of fusion and fission executed by dynamin-like GTPases …

At different stages of spermatogenesis, germ cell mitochondria differ remarkably in
morphology, architecture, and functions. However, it remains elusive how mitochondria …

MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2) are GTPases essential for mitochondrial fusion.
Published studies revealed crucial roles of both Mitofusins during embryonic development …