Bacterial siderophores: diversity, uptake pathways and applications

IJ Schalk - Nature Reviews Microbiology, 2024 - nature.com
Iron is an essential nutrient for the growth, survival and virulence of almost all bacteria. To
access iron, many bacteria produce siderophores, molecules with a high affinity for iron …

Role of iron in the molecular pathogenesis of diseases and therapeutic opportunities

U Abbasi, S Abbina, A Gill, LE Takuechi… - ACS Chemical …, 2021 - ACS Publications
Iron is an essential mineral that serves as a prosthetic group for a variety of proteins involved
in vital cellular processes. The iron economy within humans is highly conserved in that there …

A Ce-MOF@ polydopamine composite nanozyme as an efficient scavenger for reactive oxygen species and iron in thalassemia disease therapy

Y Duan, L Liang, F Ye, S Zhao - Nanoscale, 2023 - pubs.rsc.org
Patients with β-thalassemia are prone to complications such as cardiovascular diseases and
secretory gland injury due to iron overload (IO) and reactive oxygen species (ROS) …

Efficient iron and ROS nanoscavengers for brain protection after intracerebral hemorrhage

F Zhu, L Zi, P Yang, Y Wei, R Zhong… - … Applied Materials & …, 2021 - ACS Publications
Intracerebral hemorrhage (ICH) will be accompanied by the overload of iron and reactive
oxygen species (ROS) following hematoma clearance. Although deferoxamine (DFO) has …

Reactive oxygen species-triggered dissociation of a polyrotaxane-based nanochelator for enhanced clearance of systemic and hepatic iron

Z Liu, GA Simchick, J Qiao, MM Ashcraft, S Cui… - ACS …, 2020 - ACS Publications
Chronic blood transfusions are used to alleviate anemic symptoms in thalassemia and sickle
cell anemia patients but can eventually result in iron overload (IO) and subsequently lead to …

Facile Synthesis of Water-Soluble Rhodamine-Based Polymeric Chemosensors via Schiff Base Reaction for Fe3+ Detection and Living Cell Imaging

X Qiu, J Huang, N Wang, K Zhao, J Cui… - Frontiers in Chemistry, 2022 - frontiersin.org
Quantitative and accurate determination of iron ions play a vital role in maintaining
environment and human health, but very few polymeric chemosensors were available for the …

A nanocellulose-based colorimetric assay kit for smartphone sensing of iron and iron-chelating deferoxamine drug in biofluids

S Faham, H Golmohammadi, R Ghavami… - Analytica chimica …, 2019 - Elsevier
The current work describes the development of a “nanopaper-based analytical device
(NAD)”, through the embedding of curcumin in transparent bacterial cellulose (BC) …

Deferoxamine-Based Materials and Sensors for Fe (III) Detection

G Alberti, C Zanoni, LR Magnaghi, R Biesuz - Chemosensors, 2022 - mdpi.com
Deferoxamine (DFO) is a siderophore widely studied for its ability to bind iron (III) strongly.
Thanks to its versatility, it is suitable for several clinical and analytical applications, from the …

N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson's Disease

L Mursaleen, B Noble, SHY Chan, S Somavarapu… - Antioxidants, 2020 - mdpi.com
Oxidative stress is a key mediator in the development and progression of Parkinson's
disease (PD). The antioxidant N-acetylcysteine (NAC) has generated interest as a disease …

Iron Chelation as a Potential Therapeutic Approach in Acute Lung Injury

X Zhang, J Zhou, BE Holbein, C Lehmann - Life, 2023 - mdpi.com
Acute lung injury (ALI) has been challenging health care systems since before the COVID-
19 pandemic due to its morbidity, mortality, and length of hospital stay. In view of the …