Update on COVID-19 therapeutics for solid organ transplant recipients, including the omicron surge

RK Avery - Transplantation, 2022 - journals.lww.com
Major changes have occurred in therapeutics for coronavirus-19 (COVID-19) infection over
the past 12–18 mo, most notably in early outpatient therapy. In most cases, solid organ …

[HTML][HTML] Real-world experience with available, outpatient COVID-19 therapies in solid organ transplant recipients during the omicron surge

C Radcliffe, CF Palacios, MM Azar, E Cohen… - American Journal of …, 2022 - Elsevier
The SARS-CoV-2 pandemic continues to place a substantial burden on healthcare systems.
Outpatient therapies for mild-to-moderate disease have reduced hospitalizations and deaths …

Issues regarding COVID-19 in kidney transplantation in the ERA of the Omicron variant: a commentary by the ERA Descartes Working Group

I Gandolfini, M Crespo, R Hellemans… - Nephrology Dialysis …, 2022 - academic.oup.com
The Omicron variant, which has become the dominant strain of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) worldwide, brings new challenges to preventing and …

Outcomes of bebtelovimab and sotrovimab treatment of solid organ transplant recipients with mild‐to‐moderate coronavirus disease 2019 during the Omicron epoch

ZA Yetmar, E Beam, JC O'Horo… - Transplant Infectious …, 2022 - Wiley Online Library
Background Solid organ transplant recipients (SOTRs) are at high‐risk for severe infection
from severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Anti‐spike …

COVID-19 Mortality in Vaccinated vs. Unvaccinated Liver & Kidney Transplant Recipients: A Single-Center United States Propensity Score Matching Study on …

H Hardgrave, A Wells, J Nigh, G Klutts, D Krinock… - Vaccines, 2022 - mdpi.com
Introduction: Existing studies report variable impact of vaccination on Coronavirus Disease
(COVID-19) morbidity and mortality in solid organ transplant (SOT) recipients. This study …

[HTML][HTML] Monoclonal antibody therapy in kidney transplant recipients with delta and omicron variants of SARS-CoV-2: a single-center case series

G Fernandes, A Devresse, A Scohy, J De Greef… - Kidney medicine, 2022 - Elsevier
Rationale & Objective Neutralizing monoclonal antibody treatments have shown promising
preliminary results in kidney transplant recipients infected with severe acute respiratory …

Clinical outcomes of SARS-CoV-2 breakthrough infections in liver transplant recipients during the omicron wave

A Herting, J Jahnke-Triankowski, A Harberts… - Viruses, 2023 - mdpi.com
At the start of the pandemic, liver transplant recipients (LTR) were at high risk of developing
severe COVID-19. Here, the outcomes of breakthrough infections in fully vaccinated LTR (n …

Early treatment with monoclonal antibodies or convalescent plasma reduces mortality in non-vaccinated COVID-19 high-risk patients

L Thümmler, M Lindemann, PA Horn, V Lenz, M Konik… - Viruses, 2022 - mdpi.com
Vulnerable patients such as immunosuppressed or elderly patients are at high risk for a
severe course of COVID-19 upon SARS-CoV-2 infection. Immunotherapy with SARS-CoV-2 …

[HTML][HTML] Monoclonal antibody therapy improves severity and mortality of COVID-19 in organ transplant recipients: a meta-analysis

M Yang, A Li, Y Wang, C Tran, S Zhao… - The Journal of …, 2022 - ncbi.nlm.nih.gov
According to the WHO, more than 30 million children under five years of age still suffer from
vaccine-preventable diseases (VPDs) every year in Africa. 1 Of these, over half a million die …

Treatment with sotrovimab for SARS-CoV-2 infection in a cohort of high-risk kidney transplant recipients

F Villanego, A Mazuecos, B Cubillo… - Clinical Kidney …, 2022 - academic.oup.com
Background Sotrovimab is a neutralizing monoclonal antibody (mAb) that seems to remain
active against recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …