Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer
various gain-of-function (GOF) activities that impacts molecules and pathways now regarded …

GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to
promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on …

Circular RNAs (circRNAs), one kind of noncoding RNAs, can interact with miRNA and
transcription factors to regulate gene expression. However, little is known on which circRNA …

Temozolomide (TMZ) is widely used for treating glioblastoma multiforme (GBM), however,
the treatment of such brain tumors remains a challenge due to the development of …

The majority of women diagnosed with epithelial ovarian cancer eventually develop
recurrence, which rapidly evolves into chemoresistant disease. Persistence of ovarian …

Abstract Ethnopharmacological relevance Jiawei Yanghe Decoction (JWYHD) is a widely
used traditional Chinese medicine prescription in the clinical setting for the treatment of …

Metabolic reprogramming has become increasingly important in tumor biology research.
The glucose metabolic pathway is a major energy source and is often dysregulated in breast …

Acquired and intrinsic resistance to receptor tyrosine kinase inhibitors (RTKi) represents a
major hurdle in improving the management of clear cell renal cell carcinoma (ccRCC) …

Ras-specific GTPase-activating proteins (RasGAPs) down-regulate the biological activity of
Ras proteins by accelerating their intrinsic rate of GTP hydrolysis, basically by a transition …

Abstract Purpose of Review An important number of newly identified molecular alterations in
prostate cancer affect gene encoding master regulators of chromatin biology epigenetic …