Approximately one percent of the human genome encodes proteins that either regulate or
are regulated by direct interaction with members of the Rho family of small GTPases …

Formins are a widely expressed family of proteins that govern cell shape, adhesion,
cytokinesis, and morphogenesis by remodeling the actin and microtubule cytoskeletons …

Formin proteins were recognized as effectors of Rho GTPases some 15 years ago. They
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …

Formins are conserved actin polymerization machines that have instrumental roles in
controlling rearrangements of the actin cytoskeleton and have recently been shown to …

Motile and morphogenetic cellular processes are driven by site-directed assembly of actin
filaments. Formins, proteins characterized by formin homology domains FH1 and FH2, are …

Myelodysplastic syndromes (MDS) are age-related myeloid neoplasms with increased risk
of progression to acute myeloid leukemia (AML). The mechanisms of transformation of MDS …

The mechanism underlying cytokinesis, the final step in cell division, remains one of the
major unsolved questions in basic cell biology. Thanks to advances in functional genomics …

Actin polymerization-driven protrusion of the leading edge is a key element of cell motility.
The important actin nucleators formins and the Arp2/3 complex are believed to have …

Formin proteins are potent regulators of actin dynamics. Most eukaryotes have multiple
formin isoforms, suggesting diverse cellular roles. Formins are modular proteins, containing …

Formins constitute a diverse protein family present in all eukaryotes examined. They are
defined by the presence of a formin homology 2 (FH2) domain, which possesses intrinsic …