Advancements in melanoma cancer metastasis models

LM Nascentes Melo, S Kumar, V Riess… - Pigment cell & …, 2023 - Wiley Online Library
Metastatic melanoma is a complex and deadly disease. Due to its complexity, the
development of novel therapeutic strategies to inhibit metastatic melanoma remains an …

[HTML][HTML] Benzamide derivative radiotracers targeting melanin for melanoma imaging and therapy: Preclinical/clinical development and combination with other …

J Rouanet, M Quintana, P Auzeloux, F Cachin… - Pharmacology & …, 2021 - Elsevier
Cutaneous melanoma arises from proliferating melanocytes, cells specialized in the
production of melanin. This property means melanin can be considered as a target for …

In vivo imaging of invasive aspergillosis with 18F-fluorodeoxysorbitol positron emission tomography

DY Kim, A Pyo, S Ji, SH You, SE Kim, D Lim… - Nature …, 2022 - nature.com
Invasive aspergillosis is a critical complication in immunocompromised patients with
hematologic malignancies or with viral pneumonia caused by influenza virus or SARS‑CoV …

Melanin-targeting radiotracers and their preclinical, translational, and clinical status: from past to future

X Zhang, Z Lin, Y Feng, F Kang, J Wang… - Journal of Nuclear …, 2024 - Soc Nuclear Med
Melanin is one of the representative biomarkers of malignant melanoma and a potential
target for diagnosis and therapy. With advancements in chemistry and radiolabeling …

Synthesis and Preclinical Evaluation of a 68Ga-Labeled Pyridine-Based Benzamide Dimer for Malignant Melanoma Imaging

T Wang, P Xu, J Fang, C Li, X Zeng, J Liu… - Molecular …, 2022 - ACS Publications
Benzamide (BZA), a small molecule that can freely cross cell membranes and bind to
melanin, has served as an effective targeting group for melanoma theranostics. In this study …

Synthesis and evaluation of 18F-labeled procainamide as a PET imaging agent for malignant melanoma

A Pyo, M Yun, B Song, SY Kwon, JJ Min… - Bioorganic & Medicinal …, 2023 - Elsevier
Malignant melanoma has an aggressive nature and a high metastatic propensity resulting in
the highest mortality rate of any skin cancer. In this study, we synthesized 18 F-labeled …

Comparison of a Series of 68Ga-Labeled DOTA-LLP2A Conjugates for Positron Emission Tomography Imaging of Very Late Antigen-4 in Melanoma

P Zhou, Y Wu, G Han, J Jiang, H Wang… - Molecular …, 2025 - ACS Publications
Melanoma, with its steadily rising global incidence, is characterized by high invasiveness,
leading to poor prognosis in advanced stages. There remains an unmet clinical need for the …

Translating molecules into imaging—the development of new PET tracers for patients with melanoma

L Vercellino, D de Jong, L Dercle, B Hosten… - Diagnostics, 2022 - mdpi.com
Melanoma is a deadly disease that often exhibits relentless progression and can have both
early and late metastases. Recent advances in immunotherapy and targeted therapy have …

MC1R and melanin-based molecular probes for theranostic of melanoma and beyond

H Shi, Z Cheng - Acta Pharmacologica Sinica, 2022 - nature.com
Malignant melanoma is accounting for most of skin cancer-associated mortality. The
incidence of melanoma increased every year worldwide especially in western countries …

[HTML][HTML] A PET Probe Targeting Polyamine Transport System for Precise Tumor Diagnosis and Therapy

M Zhou, X Yin, B Chen, S Hu, W Zhou - Asian Journal of Pharmaceutical …, 2024 - Elsevier
Polyamine metabolism dysregulation is a hallmark of many cancers, offering a promising
avenue for early tumor theranostics. This study presents the development of a nuclear probe …