Lipoxygenases (LOXs) catalyze the stereo-specific peroxidation of polyunsaturated fatty
acids (PUFAs) to their corresponding hydroperoxy derivatives. Human macrophages …

Lipoxygenases (LOXs) are lipid metabolizing enzymes that catalyze the di-oxygenation of
polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12 …

The oxidative degradation of lipids has been shown to be implicated in the progression of
several neurodegenerative diseases and modulating lipid peroxidation may be efficacious …

Objective Mitochondrial dysfunction plays a dominant role in the pathogenesis of alcoholic
liver disease (ALD); however, the underlying mechanisms remain to be fully understood. We …

Background and Aims In general, physical activity (PA) and nonalcoholic fatty liver disease
(NAFLD) have an inverse association. However, studies assessing the impact of the widely …

Reactive oxygen species (ROS) are generally recognized as major products in the cells that
are produced during oxygen utilization, cellular breakdown, and the incomplete degradation …

Aging is a major risk factor for metabolic disorders. Polyunsaturated fatty acid-derived
bioactive lipids play critical roles as signaling molecules in metabolic processes …

Hydroxynonenal (HNE) is an important product of plasma membrane lipid peroxidation,
which is a cause of cell and tissue injury. Mitochondrial DNA (mtDNA)‐depleted ρ0 cells …

Background and Aims Alcohol‐associated liver disease (ALD) is a common chronic liver
disease worldwide with high morbidity and mortality, and no Food and Drug Administration …

Background and Aims Forkhead box M1 (FOXM1) and nuclear factor kappa B (NF‐ĸB) are
oncogenic drivers in liver cancer that positively regulate each other. We showed that …