Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …

Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The …

Recent studies have brought to light the necessity to discern sex-specific differences in
various pain states and different cell-types that mediate these differences. These studies …

This review reflects upon our own as well as other investigators' studies on the role of
receptor for advanced glycation end-products (RAGE), bringing up the latest information on …

Patients with diabetes develop endothelial dysfunction shortly after diabetes onset that
progresses to vascular disease underlying the majority of diabetes-associated …

Advanced glycation end products (AGEs) are a series of stable compounds produced under
non-enzymatic conditions by the amino groups of biomacromolecules and the free carbonyl …

Background and aim Pathogenesis of COVID-19-related headache is unknown, though the
induction of the trigeminal neurons through inflammation is proposed. We aimed to …

Progress in the development of effective chemotherapy is producing a growing population of
patients with acute and chronic painful chemotherapy-induced peripheral neuropathy …

Pain is one of the most significant causes of suffering and disability world-wide, and
arguably the most burdensome global health challenge. The growing number of patients …

Vascular endothelial growth factor (VEGF) is a pro-angiogenic factor that mediates the
differentiation and function of vascular endothelial cells. VEGF has been implicated in …