The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …

A recurrent theme in embryonic development and tissue regeneration is that cells
communicate with each other using just a handful of conserved families of signaling …

Tooth enamel secreted by ameloblasts (AMs) is the hardest material in the human body,
acting as a shield to protect the teeth. However, the enamel is gradually damaged or …

Mammalian dentition consists of teeth that develop as discrete organs. From anterior to
posterior, the dentition is divided into regions of incisor, canine, premolar and molar tooth …

Pax genes have been shown to play important roles in mammalian development and
organogenesis. Pax9, a member of this transcription factor family, is expressed in somites …

There has been rapid progress recently in the identification of signalling pathways
regulating tooth development. It has become apparent that signalling networks involved in …

A wealth of information has recently become available on the molecular signals that are
required to form and pattern the dentition in the mouse, shedding light on how important …

The bone morphogenetic proteins (BMPs) constitute a large family of cytokines related to
members of the transforming growth factor-β superfamily. Recent evidence, in particular from …

All ectodermal organs, eg hair, teeth, and many exocrine glands, originate from two adjacent
tissue layers: the epithelium and the mesenchyme. Similar sequential and reciprocal …

Dental agenesis is the most common developmental anomaly in humans and is frequently
associated with several other oral abnormalities. Whereas the incidence of missing teeth …