Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds

JA Domínguez-Avila, A Wall-Medrano… - Food & Function, 2017 - pubs.rsc.org
The positive health effects of phenolic compounds (PCs) have been extensively reported in
the literature. An understanding of their bioaccessibility and bioavailability is essential for the …

Biotransformation and gut microbiota-mediated bioactivity of flavonols

M Wang, Y Lu, Q Wu, G Chen, H Zhao… - Journal of agricultural …, 2023 - ACS Publications
Consumption of fruits and vegetables has been associated with a reduced risk of multiple
diseases, such as metabolic disorders. Flavonols are the most ubiquitous flavonoids in fruits …

Natural deep eutectic solvents (NADES) as a tool for bioavailability improvement: pharmacokinetics of rutin dissolved in proline/glycine after oral administration in rats …

M Faggian, S Sut, B Perissutti, V Baldan, I Grabnar… - Molecules, 2016 - mdpi.com
There is a need for innovation in plant-derived pharmaceuticals, food supplements and
nutraceutical products regarding the use of more eco-sustainable solvents for their …

Influence factors of the pharmacokinetics of herbal resourced compounds in clinical practice

S Sun, Y Wang, A Wu, Z Ding… - … Based Complementary and …, 2019 - Wiley Online Library
Herbal medicines have been used to prevent and cure diseases in eastern countries for
thousands of years. In recent decades, these phytotherapies are becoming more and more …

[HTML][HTML] Evaluation of the protective effects of quercetin and gallic acid against oxidative toxicity in rat's kidney and HEK-293 cells

SO Abarikwu, G Simple, SC Onuoha, I Mokwenye… - Toxicology reports, 2020 - Elsevier
Quercetin and gallic acid are phytochemicals with interesting pharmacological properties.
We herein investigated the protective effect of quercetin (QUE) in comparison with gallic acid …

[HTML][HTML] Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus

M Martiniakova, A Sarocka, N Penzes, R Biro… - Nutrients, 2025 - mdpi.com
Type 2 diabetes mellitus (T2DM), a serious metabolic disorder, is a worldwide health
problem due to the alarming rise in prevalence and elevated morbidity and mortality …

Anti-inflammatory Potential of Flavonoids from the Aerial Parts of Corispermum marschallii

K Pawłowska, ME Czerwińska, M Wilczek… - Journal of natural …, 2018 - ACS Publications
The isolation of phenolics from aerial parts of Corispermum marschallii yielded a total of 13
compounds including nine previously undescribed patuletin and spinacetin glycosides …

[HTML][HTML] Multi-component pharmacokinetics assessment of Artemisia annua L. in rats based on LC-ESI-MS/MS quantification combined with molecular docking

C Fu, K Zhang, M Wang, F Qiu - Arabian Journal of Chemistry, 2022 - Elsevier
Artemisia annua L.(A. annua) has been used as herbal medicine in China for thousands of
years for clearing deficiency heat, treating malaria and removing jaundice. A rapid, sensitive …

Development of a HPLC‐MS/MS Method to Determine the 13 Elements of Semen Cuscutae and Application to a Pharmacokinetic Study in Rats

J Shen, Q Jia, X Huang, G Yao, W Ma… - Evidence‐Based …, 2019 - Wiley Online Library
This study developed a method for simultaneous determination of 13 elements of Semen
Cuscutae (quercitrin, quercetin, hyperoside, caffeic acid, chlorogenic acid, luteolin, apigenin …

[HTML][HTML] Osteoclast differentiation is downregulated by select polyphenolic fractions from dried plum via suppression of MAPKs and Nfatc1 in mouse C57BL/6 primary …

JL Graef, E Rendina-Ruedy, EK Crockett… - Current developments in …, 2017 - Elsevier
Background Clinical and preclinical studies have shown that dietary supplementation with
dried plum improves bone health. These osteoprotective effects are a result, in part, of the …