Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics
AS Nam, R Chaligne, DA Landau - Nature Reviews Genetics, 2021 - nature.com
Cancer represents an evolutionary process through which growing malignant populations
genetically diversify, leading to tumour progression, relapse and resistance to therapy. In …
genetically diversify, leading to tumour progression, relapse and resistance to therapy. In …
Targeting signaling pathways in prostate cancer: mechanisms and clinical trials
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …
genomic landscapes and biological functions, the treatment of PCa continues to improve …
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR)
dependence leads to clinically aggressive tumors with few therapeutic options. We used …
dependence leads to clinically aggressive tumors with few therapeutic options. We used …
Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer
Tumor expression of prostate-specific membrane antigen (PSMA) is lost in 15–20% of men
with castration-resistant prostate cancer (CRPC), yet the underlying mechanisms remain …
with castration-resistant prostate cancer (CRPC), yet the underlying mechanisms remain …
The DNA methylation landscape of advanced prostate cancer
Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …
methylation landscape of metastatic cancer has never been defined. Through whole …
Emergence of a high-plasticity cell state during lung cancer evolution
ND Marjanovic, M Hofree, JE Chan, D Canner, K Wu… - Cancer cell, 2020 - cell.com
Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly
understood. Here, we profile single-cell transcriptomes of genetically engineered mouse …
understood. Here, we profile single-cell transcriptomes of genetically engineered mouse …
Inter-and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling
Metastatic prostate cancer (mPC) comprises a spectrum of diverse phenotypes. However,
the extent of inter-and intra-tumor heterogeneity is not established. Here we use digital …
the extent of inter-and intra-tumor heterogeneity is not established. Here we use digital …
Genomic and phenotypic heterogeneity in prostate cancer
From a clinical, morphological and molecular perspective, prostate cancer is a
heterogeneous disease. Primary prostate cancers are often multifocal, having …
heterogeneous disease. Primary prostate cancers are often multifocal, having …
Ectopic JAK–STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance
Emerging evidence indicates that various cancers can gain resistance to targeted therapies
by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations …
by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations …
Emerging role of tumor cell plasticity in modifying therapeutic response
Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …
have proposed that acquisition of resistance may result from genetic mutations. However …