Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer

CAK Borrebaeck - Nature Reviews Cancer, 2017 - nature.com
Interest in precision diagnostics has been fuelled by the concept that early detection of
cancer would benefit patients; that is, if detected early, more tumours should be resectable …

Parallel reaction monitoring using quadrupole‐Orbitrap mass spectrometer: principle and applications

A Bourmaud, S Gallien, B Domon - Proteomics, 2016 - Wiley Online Library
Targeted mass spectrometry‐based approaches are nowadays widely used for quantitative
proteomics studies and more recently have been implemented on high resolution/accurate …

[HTML][HTML] Orbitrap mass spectrometry

RA Zubarev, A Makarov - 2013 - ACS Publications
Orbitrap Mass Spectrometry | Analytical Chemistry ACS ACS Publications C&EN CAS Find my
institution Log In Analytical Chemistry ACS Publications. Most Trusted. Most Cited. Most Read …

[HTML][HTML] Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer

A Michalski, E Damoc, JP Hauschild, O Lange… - Molecular & cellular …, 2011 - ASBMB
Mass spectrometry-based proteomics has greatly benefitted from enormous advances in
high resolution instrumentation in recent years. In particular, the combination of a linear ion …

Highly parallel single-molecule identification of proteins in zeptomole-scale mixtures

J Swaminathan, AA Boulgakov, ET Hernandez… - Nature …, 2018 - nature.com
The identification and quantification of proteins lags behind DNA-sequencing methods in
scale, sensitivity, and dynamic range. Here, we show that sparse amino acid–sequence …

A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides

JM Chick, D Kolippakkam, DP Nusinow, B Zhai… - Nature …, 2015 - nature.com
Fewer than half of all tandem mass spectrometry (MS/MS) spectra acquired in shotgun
proteomics experiments are typically matched to a peptide with high confidence. Here we …

[HTML][HTML] An improved boosting to amplify signal with isobaric labeling (iBASIL) strategy for precise quantitative single-cell proteomics

CF Tsai, R Zhao, SM Williams, RJ Moore… - Molecular & Cellular …, 2020 - ASBMB
Mass spectrometry (MS)-based proteomics has great potential for overcoming the limitations
of antibody-based immunoassays for antibody-independent, comprehensive, and …

Proteomics by mass spectrometry: approaches, advances, and applications

JR Yates, CI Ruse… - Annual review of …, 2009 - annualreviews.org
Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale
proteomics. In this review, we dissect the overall framework of the MS experiment into its key …

[HTML][HTML] Mass spectrometry imaging with high resolution in mass and space

A Römpp, B Spengler - Histochemistry and cell biology, 2013 - Springer
Mass spectrometry (MS) imaging links molecular information and the spatial distribution of
analytes within a sample. In contrast to most histochemical techniques, mass spectrometry …

[HTML][HTML] Cervicovaginal microbiome dysbiosis is associated with proteome changes related to alterations of the cervicovaginal mucosal barrier

H Borgdorff, R Gautam, SD Armstrong, D Xia… - Mucosal …, 2016 - Elsevier
Vaginal microbiome (VMB) dysbiosis is associated with increased acquisition of HIV.
Cervicovaginal inflammation and other changes to the mucosal barrier are thought to have …