NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

[HTML][HTML] Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD

DG Mashek - Molecular metabolism, 2021 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …

Mitochondrial dysfunction plays central role in nonalcoholic fatty liver disease

R Ramanathan, AH Ali, JA Ibdah - International Journal of Molecular …, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is a global pandemic that affects one-quarter of the
world's population. NAFLD includes a spectrum of progressive liver disease from steatosis to …

[HTML][HTML] Emerging roles of SIRT1 in fatty liver diseases

RB Ding, J Bao, CX Deng - International journal of biological …, 2017 - ncbi.nlm.nih.gov
Fatty liver diseases, which are commonly associated with high-fat/calorie diet, heavy alcohol
consumption and/or other metabolic disorder causes, lead to serious medical concerns …

Oxidative stress in NAFLD: role of nutrients and food contaminants

C Rives, A Fougerat, S Ellero-Simatos, N Loiseau… - Biomolecules, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic
syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance …

Sirtuins, epigenetics and longevity

M Wątroba, I Dudek, M Skoda, A Stangret… - Ageing research …, 2017 - Elsevier
Aging of organisms begins from a single cell at the molecular level. It includes changes
related to telomere shortening, cell senescence and epigenetic modifications. These …

Fructose promotes leaky gut, endotoxemia, and liver fibrosis through ethanol‐inducible cytochrome P450‐2E1–mediated oxidative and nitrative stress

YE Cho, DK Kim, W Seo, B Gao, SH Yoo, BJ Song - Hepatology, 2021 - journals.lww.com
Fructose intake is known to induce obesity, insulin resistance, metabolic syndrome, and
nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the effects of fructose …

miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease

JK Long, W Dai, YW Zheng, SP Zhao - Molecular Medicine, 2019 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is a common hepatic disease with an
increasing prevalence but an unclear aetiology. This study aimed to investigate the …

Role of mitochondria in liver metabolic health and diseases

B Morio, B Panthu, A Bassot, J Rieusset - Cell Calcium, 2021 - Elsevier
The liver is a major organ that coordinates the metabolic flexibility of the whole body, which
is characterized by the ability to adapt dynamically in response to fluctuations in energy …

Effect of empagliflozin on thioacetamide-induced liver injury in rats: role of AMPK/SIRT-1/HIF-1α pathway in halting liver fibrosis

MA ElBaset, RS Salem, F Ayman, N Ayman, N Shaban… - Antioxidants, 2022 - mdpi.com
Hepatic fibrosis causes severe morbidity and death. No viable treatment can repair fibrosis
and protect the liver until now. We intended to discover the empagliflozin's (EMPA) …