Fundamental Neurochemistry Review: GABAA receptor neurotransmission and epilepsy: Principles, disease mechanisms and pharmacotherapy
Epilepsy is a common neurological disorder associated with alterations of excitation‐
inhibition balance within brain neuronal networks. GABAA receptor neurotransmission is the …
inhibition balance within brain neuronal networks. GABAA receptor neurotransmission is the …
Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations
The cerebellar cortex has a key role in generating predictive sensorimotor associations. To
do so, the granule cell layer is thought to establish unique sensorimotor representations for …
do so, the granule cell layer is thought to establish unique sensorimotor representations for …
Protein-Based Tools for Studying Neuromodulation
W Wang - ACS Chemical Biology, 2024 - ACS Publications
Neuromodulators play crucial roles in regulating neuronal activity and affecting various
aspects of brain functions, including learning, memory, cognitive functions, emotional states …
aspects of brain functions, including learning, memory, cognitive functions, emotional states …
Optical Control of Dopamine D2-like Receptors with Cell-Specific Fast-Relaxing Photoswitches
Dopamine D2-like receptors (D2R, D3R, and D4R) control diverse physiological and
behavioral functions and are important targets for the treatment of a variety of …
behavioral functions and are important targets for the treatment of a variety of …
Ketamine rescues anhedonia by cell-type and input specific adaptations in the Nucleus Accumbens
Ketamine's role in providing a rapid and sustained antidepressant response, particularly for
patients unresponsive to conventional treatments, is increasingly recognized. A core …
patients unresponsive to conventional treatments, is increasingly recognized. A core …
Cell‐Specific Optical Control of AMPA Glutamate Receptors with a Photoswitchable Tethered Antagonist
AMPA receptors (AMPARs) are the main drivers of excitatory glutamatergic transmission in
the brain, central to synaptic plasticity, and are key drug targets. However, AMPARs are …
the brain, central to synaptic plasticity, and are key drug targets. However, AMPARs are …
Reward perseveration is shaped by GABAA-mediated dopamine pauses
Extinction learning is an essential form of cognitive flexibility, which enables obsolete reward
associations to be discarded. Its downregulation can lead to perseveration, a symptom seen …
associations to be discarded. Its downregulation can lead to perseveration, a symptom seen …